Compound Detail
CHEMBL113865
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Basic Information
| ChEMBL ID | CHEMBL113865 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | HHKUEURFZCEKHR-UHFFFAOYSA-N |
1
Targets
2
Activities
1
Assay Types
0
PK Parameters
4
Publications
0
Known Names
Molecular Properties
394.5
MW (Da)
5.37
ALogP
3
HBA
1
HBD
55.8
PSA (Ų)
0.76
QED
1
Ro5 Violations
3
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
EC50 2 meas. best 6.12
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Retinoic acid receptor RXR-alpha CHEMBL2061 | EC50 | 6.12 | 6.02 | 750.0 | 2 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Retinoic acid receptor RXR-alpha | EC50 | = | 750.0 | nM | 6.12 | Effective concentration against Retinoic acid receptor RXR-alpha | 7650690 |
| Retinoic acid receptor RXR-alpha | EC50 | = | 1200.0 | nM | 5.92 | Effective concentration against Retinoic acid receptor RXR-alpha | 7650690 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 7650690 | 10.1021/jm00017a021 | Retinoic acid receptor RXR-alpha | 3 |
| 7650690 | 10.1021/jm00017a021 | Retinoic acid receptor alpha | 1 |
| 7650690 | 10.1021/jm00017a021 | Retinoic acid receptor beta | 1 |
| 7650690 | 10.1021/jm00017a021 | Retinoic acid receptor gamma | 1 |
Data from ChEMBL 36 via Core Engine