Compound Detail
CHEMBL1159826
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Basic Information
| ChEMBL ID | CHEMBL1159826 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | JVQZIHGOCREKGE-UHFFFAOYSA-N |
2
Targets
3
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
297.3
MW (Da)
-0.25
ALogP
8
HBA
3
HBD
144.7
PSA (Ų)
0.68
QED
0
Ro5 Violations
5
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 3 meas. best 4.92
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Glutamate receptor ionotropic AMPA CHEMBL2096670 | IC50 | 4.92 | 4.92 | 12000.0 | 1 |
| Unchecked CHEMBL612545 | IC50 | 4.54 | 4.54 | 29000.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Glutamate receptor ionotropic AMPA | IC50 | = | 12000.0 | nM | 4.92 | Inhibition of the binding of radioligand [3H]AMPA in the presence at high-affini... | 1825114 |
| Unchecked | IC50 | = | 29000.0 | nM | 4.54 | Inhibition of the binding of radioligand [3H]AMPA in the presence of the compoun... | 1825114 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 1825114 | 10.1021/jm00105a019 | Glutamate receptor ionotropic AMPA | 4 |
| 1825114 | 10.1021/jm00105a019 | Unchecked | 1 |
Data from ChEMBL 36 via Core Engine