Compound Detail
CHEMBL116324
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
Basic Information
| ChEMBL ID | CHEMBL116324 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | RBXCUPOYMILATN-UHFFFAOYSA-N |
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names
Molecular Properties
428.5
MW (Da)
2.86
ALogP
7
HBA
0
HBD
58.7
PSA (Ų)
0.47
QED
0
Ro5 Violations
6
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 7.89
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Vascular endothelial growth factor receptor 2 CHEMBL279 | IC50 | 7.89 | 7.89 | 13.0 | 1 |
| Vascular endothelial growth factor receptor CHEMBL2095227 | IC50 | 7.1 | 7.1 | 80.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Vascular endothelial growth factor receptor 2 | IC50 | = | 13.0 | nM | 7.89 | Inhibition of Vascular endothelial growth factor receptor 2 | 12443771 |
| Vascular endothelial growth factor receptor | IC50 | = | 80.0 | nM | 7.1 | Inhibition of VEGF-stimulated mitogenesis in endothelial cells | 12443771 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 12443771 | 10.1016/s0960-894x(02)00827-2 | Vascular endothelial growth factor receptor 2 | 1 |
| 12443771 | 10.1016/s0960-894x(02)00827-2 | Vascular endothelial growth factor receptor | 1 |
| 12443771 | 10.1016/s0960-894x(02)00827-2 | No relevant target | 1 |
Data from ChEMBL 36 via Core Engine