Compound Detail
CHEMBL1170811
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Basic Information
| ChEMBL ID | CHEMBL1170811 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | GMFIEHDHMSRPRZ-FRKPEAEDSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
407.5
MW (Da)
4.70
ALogP
4
HBA
1
HBD
72.5
PSA (Ų)
0.46
QED
0
Ro5 Violations
7
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 4.0
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Potassium channel subfamily K member 10 CHEMBL3308951 | IC50 | 4.0 | 4.0 | 100000.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Potassium channel subfamily K member 10 | IC50 | = | 100000.0 | nM | 4.0 | Inhibition of rat TREK2 channel -mediated current expressed in HEK293 at 60 mV h... | 20570515 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 20570515 | 10.1016/j.bmcl.2010.05.033 | Potassium channel subfamily K member 10 | 1 |
| 27592395 | 10.1016/j.ejmech.2016.08.042 | Molecular identity unknown | 1 |
Data from ChEMBL 36 via Core Engine