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Compound Detail

CHEMBL1172560

HYDROXYPHENYL PROPIONIC ACID
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O=C(O)CCc1ccc(O)cc1

Basic Information

ChEMBL ID CHEMBL1172560
Name HYDROXYPHENYL PROPIONIC ACID
Phase Preclinical
Structure Type MOL
InChI Key NMHMNPHRMNGLLB-UHFFFAOYSA-N
3
Targets
3
Activities
1
Assay Types
0
PK Parameters
10
Publications
0
Known Names

Molecular Properties

166.2
MW (Da)
1.41
ALogP
2
HBA
2
HBD
57.5
PSA (Ų)
0.71
QED
0
Ro5 Violations
3
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

Natural Product First in Class Prodrug

Extended Properties

Molecular Formula C9H10O3
MW 166.18
Aromatic Rings 1
Heavy Atoms 12
NP-Likeness 0.60

Activity Summary

IC50 3 meas. best 4.3

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Unchecked
CHEMBL612545
IC50 4.3 4.3 49530.0 1
Spodoptera exigua
CHEMBL613321
IC50 4.23 4.23 58660.0 1
Phenol oxidase
CHEMBL2366412
IC50 4.07 4.07 84730.0 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
22447611 10.1128/aem.00301-12 Phenol oxidase 2
22447611 10.1128/aem.00301-12 Unchecked 2
22447611 10.1128/aem.00301-12 Plutella xylostella 2
20565070 10.1021/np1000945 NON-PROTEIN TARGET 1
22280363 10.1021/jm2016182 DNA (cytosine-5)-methyltransferase 1 1
22447611 10.1128/aem.00301-12 Spodoptera exigua 1
24216089 10.1016/j.bmc.2013.10.026 Radical scavenging activity 1
28129991 10.1016/j.bmc.2017.01.012 PI3-kinase p110-alpha/p85-alpha 1
28129991 10.1016/j.bmc.2017.01.012 Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform 1
28495381 10.1016/j.bmc.2017.04.037 Casein kinase II subunit alpha 1

Data from ChEMBL 36 via Core Engine