Compound Detail
CHEMBL1187471
GALMIC Enter ChEMBL ID:
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COC(=O)[C@H](CCCCN)NC(=O)[C@]1(C)NC(=O)c2nc(oc2C)[C@](C)(C(=O)NC2c3ccccc3-c3ccccc32)NC(=O)c2nc(oc2C)[C@](C)(C(=O)NCC2CCCCC2)NC(=O)c2nc1oc2C
Basic Information
| ChEMBL ID | CHEMBL1187471 |
| Name | GALMIC |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | DOHGPSDHRIKTDB-KBAHWNQNSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
989.1
MW (Da)
4.19
ALogP
15
HBA
7
HBD
305.0
PSA (Ų)
0.07
QED
3
Ro5 Violations
12
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
Ki 1 meas. best 4.47
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Galanin receptor type 1 CHEMBL4894 | Ki | 4.47 | 4.47 | 34200.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Galanin receptor type 1 | Ki | = | 34200.0 | nM | 4.47 | Binding affinity to human GalR1 | 20121116 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 20121116 | 10.1021/jm9018349 | Galanin receptor type 1 | 1 |
| 20121116 | 10.1021/jm9018349 | Galanin receptor type 2 | 1 |
Data from ChEMBL 36 via Core Engine