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Compound Detail

CHEMBL1187833

UMECLIDINIUM
💊 Approved Drug
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💊 Approved Drug
OC(c1ccccc1)(c1ccccc1)C12CC[N+](CCOCc3ccccc3)(CC1)CC2
ChEMBL ↗ Properties Compare Identifier

Basic Information

ChEMBL ID CHEMBL1187833
Name UMECLIDINIUM
Phase Approved
Structure Type MOL
InChI Key FVTWTVQXNAJTQP-UHFFFAOYSA-N
Therapeutic ✓ Yes

Known Names

GSK-573719 GSK573719 Umeclidinium Umeclidinium cation Umeclidinium ion
0
Targets
0
Activities
0
Assay Types
0
PK Parameters
20
Publications
5
Known Names
3
Indications

Molecular Properties

428.6
MW (Da)
5.14
ALogP
2
HBA
1
HBD
29.5
PSA (Ų)
0.40
QED
1
Ro5 Violations
8
Rot. Bonds

Drug Information

Molecule Type Small molecule
First Approval 2013
Availability Prescription
Chirality Achiral

Routes of Administration

Topical

Flags

Natural Product
USAN Stem -clidinium; -ium
USAN Year 2011

Extended Properties

Molecular Formula C29H34NO2+
MW 428.60
Aromatic Rings 3
Heavy Atoms 32
NP-Likeness -0.04

Indications

Pulmonary Disease, Chronic Obstructive Asthma Hyperhidrosis

Literature References

PubMed DOI Target Context # Activities
37468498 10.1038/s41467-023-40064-9 Prostaglandin G/H synthase 1 2
37468498 10.1038/s41467-023-40064-9 Alpha-1A adrenergic receptor 2
37468498 10.1038/s41467-023-40064-9 Muscarinic acetylcholine receptor M1 2
37468498 10.1038/s41467-023-40064-9 Thromboxane A2 receptor 2
- 10.6019/CHEMBL4808148 Histone deacetylase 6 2
37468498 10.1038/s41467-023-40064-9 5-hydroxytryptamine receptor 1A 1
37468498 10.1038/s41467-023-40064-9 5-hydroxytryptamine receptor 2B 1
37468498 10.1038/s41467-023-40064-9 Histamine H3 receptor 1
37468498 10.1038/s41467-023-40064-9 Prothrombin 1
37468498 10.1038/s41467-023-40064-9 Muscarinic acetylcholine receptor M2 1
37468498 10.1038/s41467-023-40064-9 D(3) dopamine receptor 1
37468498 10.1038/s41467-023-40064-9 cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A 1
37468498 10.1038/s41467-023-40064-9 Amine oxidase [flavin-containing] A 1
37468498 10.1038/s41467-023-40064-9 Mu-type opioid receptor 1
37468498 10.1038/s41467-023-40064-9 Alpha-2A adrenergic receptor 1
37468498 10.1038/s41467-023-40064-9 Sodium-dependent serotonin transporter 1
37468498 10.1038/s41467-023-40064-9 Sodium-dependent noradrenaline transporter 1
37468498 10.1038/s41467-023-40064-9 Acetylcholinesterase 1
37468498 10.1038/s41467-023-40064-9 Estrogen receptor 1
37468498 10.1038/s41467-023-40064-9 Sodium-dependent dopamine transporter 1

Data from ChEMBL 36 via Core Engine