Compound Detail
CHEMBL1189432
OLOPATADINE 💊 Approved Drug
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💊 Approved Drug
Basic Information
| ChEMBL ID | CHEMBL1189432 |
| Name | OLOPATADINE |
| Phase | Approved |
| Structure Type | MOL |
| InChI Key | JBIMVDZLSHOPLA-LSCVHKIXSA-N |
| Therapeutic | ✓ Yes |
0
Targets
0
Activities
0
Assay Types
0
PK Parameters
11
Publications
4
Known Names
6
Indications
Molecular Properties
337.4
MW (Da)
3.59
ALogP
3
HBA
1
HBD
49.8
PSA (Ų)
0.91
QED
0
Ro5 Violations
5
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| First Approval | 1996 |
| Availability | OTC |
| Chirality | Achiral |
Indications
Eye Manifestations Nasal Obstruction Conjunctivitis, Allergic Rhinitis, Allergic, Perennial Rhinitis, Allergic, Seasonal Rhinitis, Allergic, Seasonal
ATC Classification
R01AC08
olopatadine
Level 1: RESPIRATORY SYSTEM
Level 2: NASAL PREPARATIONS
S01GX09
olopatadine
Level 1: SENSORY ORGANS
Level 2: OPHTHALMOLOGICALS
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 16472241 | 10.2174/1570163043334794 | Hepatotoxicity | 18 |
| 22194678 | 10.1371/journal.pcbi.1002310 | Hepatotoxicity | 14 |
| 24088053 | 10.1021/jm400813y | D(2) dopamine receptor | 2 |
| 24088053 | 10.1021/jm400813y | D(1A) dopamine receptor | 2 |
| - | 10.6019/CHEMBL4495565 | SARS-CoV-2 | 2 |
| - | 10.6019/CHEMBL4651402 | SARS-CoV-2 | 2 |
| - | 10.6019/CHEMBL4808148 | Histone deacetylase 6 | 2 |
| 21458999 | 10.1016/j.bmc.2011.03.011 | Caco-2 | 1 |
| - | 10.1101/2020.04.21.054387 | SARS-CoV-2 | 1 |
| - | 10.6019/CHEMBL4495564 | Replicase polyprotein 1ab | 1 |
| 38318365 | 10.1016/j.isci.2024.108907 | Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 | 1 |
Data from ChEMBL 36 via Core Engine