Compound Detail
CHEMBL1194325
ACLIDINIUM 💊 Approved Drug
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💊 Approved Drug
Basic Information
| ChEMBL ID | CHEMBL1194325 |
| Name | ACLIDINIUM |
| Phase | Approved |
| Structure Type | MOL |
| InChI Key | ASMXXROZKSBQIH-VITNCHFBSA-N |
| Therapeutic | ✓ Yes |
1
Targets
3
Activities
1
Assay Types
3
PK Parameters
6
Publications
3
Known Names
1
Indications
Molecular Properties
484.7
MW (Da)
4.67
ALogP
6
HBA
1
HBD
55.8
PSA (Ų)
0.27
QED
0
Ro5 Violations
9
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| First Approval | 2012 |
| Availability | Prescription |
| Chirality | Single Enantiomer |
Indications
Pulmonary Disease, Chronic Obstructive
Activity Summary
IC50 3 meas. best 8.36
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Muscarinic acetylcholine receptor M3 CHEMBL245 | IC50 | 8.36 | 8.36 | 4.4 | 2 |
Pharmacokinetic Data
| Parameter | Value | Units | Species |
|---|---|---|---|
| CL | 64.0 | uL.min-1.(10^6cells)-1 | Homo sapiens |
| CL | 79.99 | uL.min-1.(10^6cells)-1 | Rattus norvegicus |
| CL | 140.0 | mL.min-1.g-1 | Homo sapiens |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Muscarinic acetylcholine receptor M3 | IC50 | = | 4.4 | nM | 8.36 | [3H]-NMS Binding Assay: The binding of [3H]-NMS to human muscarinic receptors wa... | - |
| Muscarinic acetylcholine receptor M3 | IC50 | = | 4.4 | nM | 8.36 | [3H]-NMS Binding Assay: Assays were carried out at 25° C. Membrane preparations ... | - |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| - | 10.6019/CHEMBL3301361 | ADMET | 3 |
| - | 10.6019/CHEMBL4495565 | SARS-CoV-2 | 2 |
| - | 10.6019/CHEMBL3301361 | No relevant target | 1 |
| 22961681 | 10.1124/dmd.112.047068 | Bile salt export pump | 1 |
| - | 10.1101/2020.04.21.054387 | SARS-CoV-2 | 1 |
| - | 10.6019/CHEMBL4495564 | Replicase polyprotein 1ab | 1 |
Data from ChEMBL 36 via Core Engine