Compound Detail
CHEMBL1195
PROPOXYCAINE 💊 Approved Drug
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💊 Approved Drug
Basic Information
| ChEMBL ID | CHEMBL1195 |
| Name | PROPOXYCAINE |
| Phase | Approved |
| Structure Type | MOL |
| InChI Key | CAJIGINSTLKQMM-UHFFFAOYSA-N |
| Therapeutic | ✓ Yes |
1
Targets
1
Activities
1
Assay Types
1
PK Parameters
6
Publications
2
Known Names
Molecular Properties
294.4
MW (Da)
2.56
ALogP
5
HBA
1
HBD
64.8
PSA (Ų)
0.56
QED
0
Ro5 Violations
9
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| First Approval | 1982 |
| Availability | Discontinued |
| Chirality | Achiral |
Activity Summary
IC50 1 meas. best 4.62
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Sodium channel alpha subunits; brain (Types I, II, III) CHEMBL2096682 | IC50 | 4.62 | 4.62 | 24000.0 | 1 |
Pharmacokinetic Data
| Parameter | Value | Units | Species |
|---|---|---|---|
| T1/2 | 0.05 | hr | Homo sapiens |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Sodium channel alpha subunits; brain (Types I, II, III) | IC50 | = | 24000.0 | nM | 4.62 | Inhibition of binding of Batrachotoxinin [3H]BTX-B to high affinity sites on vol... | 2579237 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 2579237 | 10.1021/jm00381a019 | Sodium channel alpha subunits; brain (Types I, II, III) | 2 |
| - | 10.6019/CHEMBL4651402 | SARS-CoV-2 | 2 |
| 24332655 | 10.1016/j.bmc.2013.11.049 | Unchecked | 1 |
| 29227101 | 10.1021/acs.jmedchem.7b01086 | Plasma | 1 |
| - | 10.1101/2020.04.21.054387 | SARS-CoV-2 | 1 |
| 38318365 | 10.1016/j.isci.2024.108907 | Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 | 1 |
Data from ChEMBL 36 via Core Engine