Compound Detail
CHEMBL1197564
NORKETOTIFEN 🧪 Phase II
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🧪 Phase II
Basic Information
| ChEMBL ID | CHEMBL1197564 |
| Name | NORKETOTIFEN |
| Phase | Phase II |
| Structure Type | MOL |
| InChI Key | IYSYPCSSDZBWHN-UHFFFAOYSA-N |
2
Targets
4
Activities
2
Assay Types
0
PK Parameters
0
Publications
2
Known Names
1
Indications
Molecular Properties
295.4
MW (Da)
3.67
ALogP
3
HBA
1
HBD
29.1
PSA (Ų)
0.80
QED
0
Ro5 Violations
0
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Chirality | Achiral |
Indications
Influenza, Human
Activity Summary
IC50 3 meas. best 5.7
Ki 1 meas. best 5.7
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Histamine H4 receptor CHEMBL3759 | IC50 | 5.7 | 5.7 | 2000.0 | 1 |
| Histamine H4 receptor CHEMBL3759 | Ki | 5.7 | 5.7 | 2000.0 | 1 |
| Histamine H1 receptor CHEMBL231 | IC50 | 4.96 | 4.96 | 11000.0 | 2 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Histamine H4 receptor | IC50 | = | 2000.0 | nM | 5.7 | Histamine H-4 Receptor Binding Assay: Histamine H-4 Receptor Binding Assay | - |
| Histamine H4 receptor | Ki | = | 2000.0 | nM | 5.7 | Binding Assay: The specific binding of the radioactive ligand to the receptor wa... | - |
| Histamine H1 receptor | IC50 | = | 11000.0 | nM | 4.96 | Histamine H1 Receptors Binding Assay: Affinities of the test compounds for perip... | - |
| Histamine H1 receptor | IC50 | = | 11000.0 | nM | 4.96 | Binding Assay: The specific binding of the radioactive ligand to the receptor wa... | - |
Data from ChEMBL 36 via Core Engine