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Compound Detail

CHEMBL1200574

SODIUM CHLORIDE
💊 Approved Drug
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💊 Approved Drug

Basic Information

ChEMBL ID CHEMBL1200574
Name SODIUM CHLORIDE
Phase Approved
Structure Type MOL
InChI Key FAPWRFPIFSIZLT-UHFFFAOYSA-M

Known Names

0.9% nacl 0.9% saline 0.9% saline solution Aqsia (balanced salt soln) Askina Askina jet B1655 Balanced salt Broncho saline Bss (balanced salt soln) Flowfusor Fresenius +18 more
1
Targets
58
Activities
1
Assay Types
0
PK Parameters
20
Publications
30
Known Names
20
Indications

Molecular Properties

58.4
MW (Da)

Drug Information

Molecule Type Small molecule
First Approval 1982
Availability Prescription
Chirality Achiral

Routes of Administration

Oral Parenteral Topical
USAN Year 1963

Extended Properties

Molecular Formula ClNa
MW 58.44

Indications

Acid-Base Imbalance Common Cold Common Cold Corneal Edema Diabetes Mellitus Eye Diseases Fluid Therapy Heart Failure Heart Failure Hemorrhage Hypothermia Abscess Acute Kidney Injury Acute Lung Injury Alcoholism Alopecia Amyotrophic Lateral Sclerosis Anemia Anemia Anemia, Iron-Deficiency

ATC Classification

A12CA01
sodium chloride
Level 1: ALIMENTARY TRACT AND METABOLISM
Level 2: MINERAL SUPPLEMENTS
B05CB01
sodium chloride
Level 1: BLOOD AND BLOOD FORMING ORGANS
Level 2: BLOOD SUBSTITUTES AND PERFUSION SOLUTIONS
B05XA03
sodium chloride
Level 1: BLOOD AND BLOOD FORMING ORGANS
Level 2: BLOOD SUBSTITUTES AND PERFUSION SOLUTIONS
S01XA03
sodium chloride, hypertonic
Level 1: SENSORY ORGANS
Level 2: OPHTHALMOLOGICALS

Activity Summary

Ki 58 meas. best 4.28

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Unchecked
CHEMBL612545
 Ki 4.28 4.28 52000.0 1

Activity Data Samples

Top measurements by pChEMBL value

Target Type Rel. Value Units pChEMBL Assay PubMed
Unchecked Ki = 52000.0 nM 4.28 Inhibition of Streptococcus pneumoniae beta-carbonic anhydrase after 15 mins by ... 21163660

Literature References

PubMed DOI Target Context # Activities
22194678 10.1371/journal.pcbi.1002310 Hepatotoxicity 14
- 10.1016/j.cropro.2007.02.008 Lasiodiplodia theobromae 12
- 10.1016/j.cropro.2007.02.008 Thielaviopsis paradoxa 12
- 10.1016/j.cropro.2007.02.008 Colletotrichum musae 12
- 10.1016/j.cropro.2007.02.008 Fusarium verticillioides 12
27914949 10.1016/j.bmc.2016.11.021 Unchecked 4
23200251 10.1016/j.bmcl.2012.10.103 Unchecked 3
21966950 10.1021/jm200920s Suppressor of tumorigenicity 14 protein 3
26145820 10.1016/j.bmc.2015.06.021 Unchecked 3
21570835 10.1016/j.bmcl.2011.04.105 Unchecked 2
23414807 10.1016/j.bmcl.2013.01.084 Unchecked 2
22835873 10.1016/j.bmcl.2012.06.106 Unchecked 2
28238511 10.1016/j.bmc.2017.02.032 Unchecked 2
25168748 10.1016/j.bmcl.2014.08.014 Unchecked 2
23414801 10.1016/j.bmcl.2013.01.087 Unchecked 2
- 10.1016/j.cropro.2007.02.008 Musa acuminata AAA Group 2
28754318 10.1016/j.bmc.2017.07.033 Unchecked 2
24461298 10.1016/j.bmcl.2013.12.124 Unchecked 2
181577 10.1021/jm00229a008 Mus musculus 2
23790722 10.1016/j.bmc.2013.05.058 Unchecked 2

Data from ChEMBL 36 via Core Engine