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Compound Detail

CHEMBL1200690

LYPRESSIN
💊 Approved Drug
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💊 Approved Drug
NCCCC[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CSSC[C@H](N)C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N1)C(=O)NCC(N)=O
ChEMBL ↗ Properties Compare Identifier

Basic Information

ChEMBL ID CHEMBL1200690
Name LYPRESSIN
Phase Approved
Structure Type BOTH
InChI Key BJFIDCADFRDPIO-DZCXQCEKSA-N
Therapeutic ✓ Yes

Known Names

8-l-lysinevasopressin Diapid L-8 Lipresina Lypressin Lypressine Lysine vasopressin Vasopressin pig Vasopressin, 8-l-lysine
0
Targets
0
Activities
0
Assay Types
0
PK Parameters
20
Publications
9
Known Names
1
Mechanisms

Molecular Properties

1056.2
MW (Da)

Drug Information

Molecule Type Protein
First Approval 1982
Availability Discontinued
Chirality Single Enantiomer

Routes of Administration

Topical

Flags

Natural Product
USAN Stem -pressin
USAN Year 1965

Extended Properties

Molecular Formula C46H65N13O12S2
MW 1056.24

Mechanism of Action

Mechanism Action Type Target Direct Efficacy
Vasopressin receptor agonist AGONIST Vasopressin receptor ✓ ✓

ATC Classification

H01BA03
lypressin
Level 1: SYSTEMIC HORMONAL PREPARATIONS, EXCL. SEX HORMONES AND INSULINS
Level 2: PITUITARY AND HYPOTHALAMIC HORMONES AND ANALOGUES

Literature References

PubMed DOI Target Context # Activities
536993 10.1021/jm00198a011 ADMET 4
- 10.6019/CHEMBL4495565 SARS-CoV-2 4
37468498 10.1038/s41467-023-40064-9 Thromboxane A2 receptor 2
536993 10.1021/jm00198a011 Rattus norvegicus 2
722751 10.1021/jm00207a002 Rattus norvegicus 2
37468498 10.1038/s41467-023-40064-9 Prostaglandin G/H synthase 1 2
- 10.6019/CHEMBL4495564 Replicase polyprotein 1ab 2
- 10.6019/CHEMBL4808148 Histone deacetylase 6 2
37468498 10.1038/s41467-023-40064-9 Muscarinic acetylcholine receptor M1 2
37468498 10.1038/s41467-023-40064-9 Alpha-1A adrenergic receptor 2
37468498 10.1038/s41467-023-40064-9 Voltage-gated inwardly rectifying potassium channel KCNH2 1
37468498 10.1038/s41467-023-40064-9 Amine oxidase [flavin-containing] A 1
37468498 10.1038/s41467-023-40064-9 Mu-type opioid receptor 1
37468498 10.1038/s41467-023-40064-9 Sodium-dependent serotonin transporter 1
37468498 10.1038/s41467-023-40064-9 Sodium-dependent noradrenaline transporter 1
37468498 10.1038/s41467-023-40064-9 Acetylcholinesterase 1
37468498 10.1038/s41467-023-40064-9 Estrogen receptor 1
37468498 10.1038/s41467-023-40064-9 Sodium-dependent dopamine transporter 1
536993 10.1021/jm00198a011 NON-PROTEIN TARGET 1
- 10.21203/rs.3.rs-23951/v1 SARS-CoV-2 1

Data from ChEMBL 36 via Core Engine