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Compound Detail

CHEMBL1201191

LEVOCETIRIZINE
💊 Approved Drug
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💊 Approved Drug
O=C(O)COCCN1CCN([C@H](c2ccccc2)c2ccc(Cl)cc2)CC1
ChEMBL ↗ Properties Compare Identifier

Basic Information

ChEMBL ID CHEMBL1201191
Name LEVOCETIRIZINE
Phase Approved
Structure Type MOL
InChI Key ZKLPARSLTMPFCP-OAQYLSRUSA-N
Therapeutic ✓ Yes

Known Names

(-)-cetirizine (r)-cetirizine Cetirizine (r)-form Cetirizine, (-)- Cetirizine, (r)- Levocetirizina Levocetirizine Xazal Xyzal
0
Targets
0
Activities
0
Assay Types
0
PK Parameters
14
Publications
9
Known Names
12
Indications

Molecular Properties

388.9
MW (Da)
3.15
ALogP
4
HBA
1
HBD
53.0
PSA (Ų)
0.70
QED
0
Ro5 Violations
8
Rot. Bonds

Drug Information

Molecule Type Small molecule
First Approval 2007
Availability OTC
Chirality Single Enantiomer

Routes of Administration

Oral

Flags

Natural Product
USAN Year 2007

Extended Properties

Molecular Formula C21H25ClN2O3
MW 388.90
Aromatic Rings 2
Heavy Atoms 27
NP-Likeness -1.21

Indications

Hypersensitivity Asthma Dermatitis Eczema Rhinitis Rhinitis, Allergic, Perennial Rhinitis, Allergic, Seasonal Rhinitis, Allergic, Seasonal Rhinitis, Vasomotor Urticaria Colorectal Neoplasms Diabetic Nephropathies

ATC Classification

R06AE09
levocetirizine
Level 1: RESPIRATORY SYSTEM
Level 2: ANTIHISTAMINES FOR SYSTEMIC USE

Literature References

PubMed DOI Target Context # Activities
25494650 10.1021/jm501535r Molecular identity unknown 2
31514017 10.1016/j.ejmech.2019.111643 Sus scrofa 2
- 10.6019/CHEMBL4808148 Histone deacetylase 6 2
25494650 10.1021/jm501535r ADMET 1
25494650 10.1021/jm501535r Nucleic Acid 1
- 10.1101/2020.04.21.054387 SARS-CoV-2 1
31514017 10.1016/j.ejmech.2019.111643 ADMET 1
- 10.6019/CHEMBL4513141 Candida albicans 1
- 10.6019/CHEMBL4513141 Cryptococcus neoformans 1
- 10.6019/CHEMBL4513141 Escherichia coli 1
- 10.6019/CHEMBL4513141 Klebsiella pneumoniae 1
- 10.6019/CHEMBL4513141 Pseudomonas aeruginosa 1
- 10.6019/CHEMBL4513141 Acinetobacter baumannii 1
- 10.6019/CHEMBL4513141 Staphylococcus aureus 1

Data from ChEMBL 36 via Core Engine