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Compound Detail

CHEMBL1201287

DEXBROMPHENIRAMINE
💊 Approved Drug
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💊 Approved Drug
CN(C)CC[C@@H](c1ccc(Br)cc1)c1ccccn1
ChEMBL ↗ Properties Compare Identifier

Basic Information

ChEMBL ID CHEMBL1201287
Name DEXBROMPHENIRAMINE
Phase Approved
Structure Type MOL
InChI Key ZDIGNSYAACHWNL-HNNXBMFYSA-N
Therapeutic ✓ Yes

Known Names

Brompheniramine d-form Brompheniramine, (s)- Dexbromfeniramina Dexbrompheniramine
0
Targets
0
Activities
0
Assay Types
0
PK Parameters
20
Publications
4
Known Names
1
Indications

Molecular Properties

319.2
MW (Da)
3.93
ALogP
2
HBA
0
HBD
16.1
PSA (Ų)
0.83
QED
0
Ro5 Violations
5
Rot. Bonds

Drug Information

Molecule Type Small molecule
First Approval 1963
Availability Discontinued
Chirality Single Enantiomer

Routes of Administration

Oral

Flags

Natural Product

Extended Properties

Molecular Formula C16H19BrN2
MW 319.25
Aromatic Rings 2
Heavy Atoms 19
NP-Likeness -1.24

Indications

Hypersensitivity

ATC Classification

R06AB06
dexbrompheniramine
Level 1: RESPIRATORY SYSTEM
Level 2: ANTIHISTAMINES FOR SYSTEMIC USE
R06AB56
dexbrompheniramine, combinations
Level 1: RESPIRATORY SYSTEM
Level 2: ANTIHISTAMINES FOR SYSTEMIC USE

Literature References

PubMed DOI Target Context # Activities
37468498 10.1038/s41467-023-40064-9 5-hydroxytryptamine receptor 1A 3
37468498 10.1038/s41467-023-40064-9 Thromboxane A2 receptor 3
37468498 10.1038/s41467-023-40064-9 Progesterone receptor 3
37468498 10.1038/s41467-023-40064-9 Muscarinic acetylcholine receptor M2 3
37468498 10.1038/s41467-023-40064-9 Prostaglandin G/H synthase 1 3
37468498 10.1038/s41467-023-40064-9 Mu-type opioid receptor 3
37468498 10.1038/s41467-023-40064-9 Alpha-1A adrenergic receptor 3
37468498 10.1038/s41467-023-40064-9 Gamma-aminobutyric acid receptor subunit alpha-1 3
37468498 10.1038/s41467-023-40064-9 5-hydroxytryptamine receptor 2B 3
37468498 10.1038/s41467-023-40064-9 Alpha-2A adrenergic receptor 3
37468498 10.1038/s41467-023-40064-9 Muscarinic acetylcholine receptor M1 3
37468498 10.1038/s41467-023-40064-9 5-hydroxytryptamine receptor 2A 2
26948801 10.1016/j.drudis.2016.02.015 Homo sapiens 2
37468498 10.1038/s41467-023-40064-9 Estrogen receptor 2
37468498 10.1038/s41467-023-40064-9 Adenosine receptor A3 2
37468498 10.1038/s41467-023-40064-9 Amine oxidase [flavin-containing] A 2
37468498 10.1038/s41467-023-40064-9 Androgen receptor 2
37468498 10.1038/s41467-023-40064-9 cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A 2
37468498 10.1038/s41467-023-40064-9 Sodium-dependent serotonin transporter 2
37468498 10.1038/s41467-023-40064-9 Sodium-dependent dopamine transporter 2

Data from ChEMBL 36 via Core Engine