Compound Detail
CHEMBL1201368
PERINDOPRILAT 🧪 Phase II
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🧪 Phase II
CCC[C@H](N[C@@H](C)C(=O)N1[C@H](C(=O)O)C[C@@H]2CCCC[C@@H]21)C(=O)O
Basic Information
| ChEMBL ID | CHEMBL1201368 |
| Name | PERINDOPRILAT |
| Phase | Phase II |
| Structure Type | MOL |
| InChI Key | ODAIHABQVKJNIY-PEDHHIEDSA-N |
0
Targets
0
Activities
0
Assay Types
9
PK Parameters
7
Publications
6
Known Names
Molecular Properties
340.4
MW (Da)
1.46
ALogP
4
HBA
3
HBD
106.9
PSA (Ų)
0.65
QED
0
Ro5 Violations
7
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Chirality | Single Enantiomer |
Pharmacokinetic Data
| Parameter | Value | Units | Species |
|---|---|---|---|
| CL | 1.7 | mL.min-1.kg-1 | Homo sapiens |
| F | 25.0 | % | Homo sapiens |
| Fu | 0.16 | - | Homo sapiens |
| MRT | 7.6 | hr | Homo sapiens |
| PPB | 10.0 | % | Homo sapiens |
| T1/2 | 29.0 | hr | Homo sapiens |
| T1/2 | 30.0 | hr | Homo sapiens |
| T1/2 | 3.0 | hr | Homo sapiens |
| Tmax | 3.0 | hr | Homo sapiens |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 18426954 | 10.1124/dmd.108.020479 | ADMET | 4 |
| - | 10.6019/CHEMBL4495565 | SARS-CoV-2 | 2 |
| - | 10.6019/CHEMBL4808148 | Histone deacetylase 6 | 2 |
| 18426954 | 10.1124/dmd.108.020479 | NON-PROTEIN TARGET | 1 |
| 11895100 | 10.1016/s0024-3205(01)01494-1 | ATP-dependent translocase ABCB1 | 1 |
| - | 10.21203/rs.3.rs-23951/v1 | SARS-CoV-2 | 1 |
| - | 10.6019/CHEMBL4495564 | Replicase polyprotein 1ab | 1 |
Data from ChEMBL 36 via Core Engine