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Compound Detail

CHEMBL1206245

BRICICLIB
🧪 Phase II
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🧪 Phase II
COc1cc(OC)c(/C=C/S(=O)(=O)Cc2ccc(OC)c(OP(=O)(O)O)c2)c(OC)c1
ChEMBL ↗ Properties Compare Identifier

Basic Information

ChEMBL ID CHEMBL1206245
Name BRICICLIB
Phase Phase II
Structure Type MOL
InChI Key LXENKEWVEVKKGV-BQYQJAHWSA-N

Known Names

Briciclib ON 014185 On-013105 ON-014185 ON014185
0
Targets
0
Activities
0
Assay Types
0
PK Parameters
4
Publications
5
Known Names
1
Indications
1
Mechanisms

Molecular Properties

474.4
MW (Da)
2.78
ALogP
8
HBA
2
HBD
137.8
PSA (Ų)
0.49
QED
0
Ro5 Violations
10
Rot. Bonds

Drug Information

Molecule Type Small molecule
Chirality Achiral

Flags

Natural Product
USAN Stem -ciclib
USAN Year 2013

Extended Properties

Molecular Formula C19H23O10PS
MW 474.42
Aromatic Rings 2
Heavy Atoms 31
NP-Likeness 0.35

Mechanism of Action

Mechanism Action Type Target Direct Efficacy
G1/S-specific cyclin D1 inhibitor INHIBITOR G1/S-specific cyclin-D1 ✓ ✓

Indications

Neoplasms

Literature References

PubMed DOI Target Context # Activities
- 10.6019/CHEMBL4495565 SARS-CoV-2 2
- 10.6019/CHEMBL4808148 Histone deacetylase 6 2
- 10.21203/rs.3.rs-23951/v1 SARS-CoV-2 1
- 10.6019/CHEMBL4495564 Replicase polyprotein 1ab 1

Data from ChEMBL 36 via Core Engine