Compound Detail

CHEMBL1208155

ELAGOLIX

💊 Approved Drug

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💊 Approved Drug

COc1cccc(-c2c(C)n(Cc3c(F)cccc3C(F)(F)F)c(=O)n(C[C@H](NCCCC(=O)O)c3ccccc3)c2=O)c1F

ChEMBL ↗ Properties Compare Identifier

Basic Information

ChEMBL ID	CHEMBL1208155
Name	ELAGOLIX
Phase	Approved
Structure Type	MOL
InChI Key	HEAUOKZIVMZVQL-VWLOTQADSA-N
Therapeutic	✓ Yes

Known Names

Elagolix NBI-56418

Targets

Activities

Assay Types

PK Parameters

Publications

Known Names

Indications

Mechanisms

Molecular Properties

631.6

MW (Da)

5.54

ALogP

HBA

HBD

102.6

PSA (Å²)

0.16

QED

Ro5 Violations

Rot. Bonds

Drug Information

Molecule Type	Small molecule
First Approval	2018
Availability	Prescription
Chirality	Single Enantiomer

Routes of Administration

Oral

Flags

First in Class

USAN Stem	-golix
USAN Year	2008

Extended Properties

Molecular Formula	C32H30F5N3O5
MW	631.60
Aromatic Rings	4
Heavy Atoms	45
NP-Likeness	-0.80

Mechanism of Action

Mechanism	Action Type	Target	Direct	Efficacy
Gonadotropin-releasing hormone receptor antagonist	ANTAGONIST	Gonadotropin-releasing hormone receptor	✓	✓

Indications

Endometriosis Polycystic Ovary Syndrome

ATC Classification

H01CC03

elagolix

Level 1: SYSTEMIC HORMONAL PREPARATIONS, EXCL. SEX HORMONES AND INSULINS

Level 2: PITUITARY AND HYPOTHALAMIC HORMONES AND ANALOGUES

Literature References

PubMed	DOI	Target Context	# Activities
-	10.6019/CHEMBL4495565	SARS-CoV-2	2
-	10.6019/CHEMBL4808148	Histone deacetylase 6	2
-	10.21203/rs.3.rs-23951/v1	SARS-CoV-2	1
-	10.6019/CHEMBL4495564	Replicase polyprotein 1ab	1
34003642	10.1021/acs.jmedchem.0c02245	Cytochrome P450 3A4	1

Data from ChEMBL 36 via Core Engine