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Compound Detail

CHEMBL120851

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CCCN(C/C=C/I)[C@@H]1CCc2ccc(O)cc2C1

Basic Information

ChEMBL ID CHEMBL120851
Phase Preclinical
Structure Type MOL
InChI Key RTMIJLQPWFKAFE-WEJQMCOXSA-N
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names

Molecular Properties

371.3
MW (Da)
3.91
ALogP
2
HBA
1
HBD
23.5
PSA (Ų)
0.79
QED
0
Ro5 Violations
5
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C16H22INO
MW 371.26
Aromatic Rings 1
Heavy Atoms 19
NP-Likeness 0.10

Activity Summary

Kd 1 meas. best 10.3

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
D(3) dopamine receptor
CHEMBL3138
Kd 10.3 10.3 0.1 1

Activity Data Samples

Top measurements by pChEMBL value

Target Type Rel. Value Units pChEMBL Assay PubMed
D(3) dopamine receptor Kd = 0.05 nM 10.3 Binding affinity was tested against dopamine receptor D3 in Sf9 cells 8277513

Literature References

PubMed DOI Target Context # Activities
8277513 10.1021/jm00078a021 D(3) dopamine receptor 1

Data from ChEMBL 36 via Core Engine