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Compound Detail

CHEMBL1213251

CLOBENZOREX
💊 Approved Drug
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💊 Approved Drug
CC(Cc1ccccc1)NCc1ccccc1Cl
ChEMBL ↗ Properties Compare Identifier

Basic Information

ChEMBL ID CHEMBL1213251
Name CLOBENZOREX
Phase Approved
Structure Type MOL
InChI Key LRXXRIXDSAEIOR-UHFFFAOYSA-N

Known Names

Clobenzorex SD 271-12 SD-271-12 SD-27112
0
Targets
0
Activities
0
Assay Types
0
PK Parameters
18
Publications
4
Known Names
1
Indications

Molecular Properties

259.8
MW (Da)
4.06
ALogP
1
HBA
1
HBD
12.0
PSA (Ų)
0.85
QED
0
Ro5 Violations
5
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Withdrawn
Chirality Racemic

Flags

Withdrawn
USAN Stem -orex

Extended Properties

Molecular Formula C16H18ClN
MW 259.78
Aromatic Rings 2
Heavy Atoms 18
NP-Likeness -1.06

Indications

Obesity

ATC Classification

A08AA08
clobenzorex
Level 1: ALIMENTARY TRACT AND METABOLISM
Level 2: ANTIOBESITY PREPARATIONS, EXCL. DIET PRODUCTS

Drug Warnings

Withdrawn
respiratory toxicity
arterial pulmonary hypertension
Country: Portugal; Oman; France   Year: 1999
Withdrawn
General Warning
unfavourable benefit/risk balance
Country: Portugal; Oman; France   Year: 1999

Literature References

PubMed DOI Target Context # Activities
15646539 10.1016/s0399-8320(04)95062-2 Unchecked 11
15646539 10.1016/s0399-8320(04)95062-2 NON-PROTEIN TARGET 8
20185316 10.1016/j.bmc.2010.01.068 Leishmania mexicana 1
20185316 10.1016/j.bmc.2010.01.068 Cryptosporidium parvum 1
20185316 10.1016/j.bmc.2010.01.068 Entamoeba histolytica 1
20185316 10.1016/j.bmc.2010.01.068 Leishmania amazonensis 1
20185316 10.1016/j.bmc.2010.01.068 Leishmania donovani 1
20185316 10.1016/j.bmc.2010.01.068 Leishmania infantum 1
20185316 10.1016/j.bmc.2010.01.068 Leishmania major 1
20185316 10.1016/j.bmc.2010.01.068 Trypanosoma cruzi 1
20185316 10.1016/j.bmc.2010.01.068 NON-PROTEIN TARGET 1
20185316 10.1016/j.bmc.2010.01.068 Plasmodium falciparum 1
20185316 10.1016/j.bmc.2010.01.068 Pneumocystis carinii 1
20185316 10.1016/j.bmc.2010.01.068 Toxoplasma gondii 1
20185316 10.1016/j.bmc.2010.01.068 Trichomonas vaginalis 1
20185316 10.1016/j.bmc.2010.01.068 Trypanosoma brucei 1
20185316 10.1016/j.bmc.2010.01.068 Trypanosoma brucei brucei 1
20185316 10.1016/j.bmc.2010.01.068 Trypanosoma brucei rhodesiense 1

Data from ChEMBL 36 via Core Engine