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Compound Detail

CHEMBL1213252

CLORAZEPIC ACID
💊 Approved Drug
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💊 Approved Drug
O=C(O)C1N=C(c2ccccc2)c2cc(Cl)ccc2NC1=O
ChEMBL ↗ Properties Compare Identifier

Basic Information

ChEMBL ID CHEMBL1213252
Name CLORAZEPIC ACID
Phase Approved
Structure Type MOL
InChI Key XDDJGVMJFWAHJX-UHFFFAOYSA-N
Therapeutic ✓ Yes

Known Names

4306-CB FREE ACID ABBOTT-35616 FREE ACID Chlorazepate Clorazepate Clorazepic acid
0
Targets
0
Activities
0
Assay Types
3
PK Parameters
20
Publications
5
Known Names

Molecular Properties

314.7
MW (Da)
2.58
ALogP
3
HBA
2
HBD
78.8
PSA (Ų)
0.84
QED
0
Ro5 Violations
2
Rot. Bonds

Drug Information

Molecule Type Small molecule
First Approval 1972
Availability Prescription
Chirality Racemic

Routes of Administration

Oral

Flags

Black Box Warning Natural Product
USAN Year 1969

Extended Properties

Molecular Formula C16H11ClN2O3
MW 314.73
Aromatic Rings 2
Heavy Atoms 22
NP-Likeness -0.30

Pharmacokinetic Data

Parameter Value Units Species
CL 1.1 mL.min-1.kg-1 Homo sapiens
MRT 3.0 hr Homo sapiens
T1/2 2.4 hr Homo sapiens

Literature References

PubMed DOI Target Context # Activities
16472241 10.2174/1570163043334794 Hepatotoxicity 18
15646539 10.1016/s0399-8320(04)95062-2 Unchecked 11
15646539 10.1016/s0399-8320(04)95062-2 NON-PROTEIN TARGET 8
18426954 10.1124/dmd.108.020479 ADMET 4
26948801 10.1016/j.drudis.2016.02.015 Homo sapiens 2
20185316 10.1016/j.bmc.2010.01.068 Leishmania major 1
29730027 10.1016/j.bmcl.2018.04.059 Mus musculus 1
20185316 10.1016/j.bmc.2010.01.068 Entamoeba histolytica 1
20185316 10.1016/j.bmc.2010.01.068 Leishmania amazonensis 1
20185316 10.1016/j.bmc.2010.01.068 Leishmania donovani 1
20185316 10.1016/j.bmc.2010.01.068 Leishmania infantum 1
20185316 10.1016/j.bmc.2010.01.068 Trypanosoma cruzi 1
20185316 10.1016/j.bmc.2010.01.068 Leishmania mexicana 1
20185316 10.1016/j.bmc.2010.01.068 NON-PROTEIN TARGET 1
20185316 10.1016/j.bmc.2010.01.068 Plasmodium falciparum 1
20185316 10.1016/j.bmc.2010.01.068 Pneumocystis carinii 1
20185316 10.1016/j.bmc.2010.01.068 Toxoplasma gondii 1
20185316 10.1016/j.bmc.2010.01.068 Trichomonas vaginalis 1
20185316 10.1016/j.bmc.2010.01.068 Trypanosoma brucei 1
20185316 10.1016/j.bmc.2010.01.068 Trypanosoma brucei brucei 1

Data from ChEMBL 36 via Core Engine