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Compound Detail

CHEMBL1213460

ETHYL LOFLAZEPATE
🧪 Phase II
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🧪 Phase II
CCOC(=O)C1N=C(c2ccccc2F)c2cc(Cl)ccc2NC1=O
ChEMBL ↗ Properties Compare Identifier

Basic Information

ChEMBL ID CHEMBL1213460
Name ETHYL LOFLAZEPATE
Phase Phase II
Structure Type MOL
InChI Key CUCHJCMWNFEYOM-UHFFFAOYSA-N

Known Names

Ethyl loflazepate Loflazepate d'ethyle Loflazepato de etilo Meilax
0
Targets
0
Activities
0
Assay Types
0
PK Parameters
19
Publications
4
Known Names
1
Indications

Molecular Properties

360.8
MW (Da)
3.20
ALogP
4
HBA
1
HBD
67.8
PSA (Ų)
0.67
QED
0
Ro5 Violations
3
Rot. Bonds

Drug Information

Molecule Type Small molecule
Chirality Racemic

Extended Properties

Molecular Formula C18H14ClFN2O3
MW 360.77
Aromatic Rings 2
Heavy Atoms 25
NP-Likeness -0.72

Indications

Anxiety

ATC Classification

N05BA18
ethyl loflazepate
Level 1: NERVOUS SYSTEM
Level 2: PSYCHOLEPTICS

Literature References

PubMed DOI Target Context # Activities
20185316 10.1016/j.bmc.2010.01.068 Leishmania mexicana 1
20020916 10.1080/15376510701857262 Phospholipidosis 1
20799726 10.1021/mp100103e Phospholipidosis 1
17428028 10.1021/ci6004542 Phospholipidosis 1
20185316 10.1016/j.bmc.2010.01.068 Cryptosporidium parvum 1
20185316 10.1016/j.bmc.2010.01.068 Entamoeba histolytica 1
20185316 10.1016/j.bmc.2010.01.068 Leishmania amazonensis 1
20185316 10.1016/j.bmc.2010.01.068 Leishmania donovani 1
20185316 10.1016/j.bmc.2010.01.068 Leishmania infantum 1
20185316 10.1016/j.bmc.2010.01.068 Leishmania major 1
20185316 10.1016/j.bmc.2010.01.068 Trypanosoma cruzi 1
20185316 10.1016/j.bmc.2010.01.068 NON-PROTEIN TARGET 1
20185316 10.1016/j.bmc.2010.01.068 Plasmodium falciparum 1
20185316 10.1016/j.bmc.2010.01.068 Pneumocystis carinii 1
20185316 10.1016/j.bmc.2010.01.068 Toxoplasma gondii 1
20185316 10.1016/j.bmc.2010.01.068 Trichomonas vaginalis 1
20185316 10.1016/j.bmc.2010.01.068 Trypanosoma brucei 1
20185316 10.1016/j.bmc.2010.01.068 Trypanosoma brucei brucei 1
20185316 10.1016/j.bmc.2010.01.068 Trypanosoma brucei rhodesiense 1

Data from ChEMBL 36 via Core Engine