Compound Detail
CHEMBL1214618
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Basic Information
| ChEMBL ID | CHEMBL1214618 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | GVUWTVHHNXJVEM-UHFFFAOYSA-N |
1
Targets
2
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
414.5
MW (Da)
4.66
ALogP
5
HBA
2
HBD
97.0
PSA (Ų)
0.51
QED
0
Ro5 Violations
4
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 7.47
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Serine/threonine-protein kinase B-raf CHEMBL5145 | IC50 | 7.47 | 6.465 | 34.0 | 2 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Serine/threonine-protein kinase B-raf | IC50 | = | 34.0 | nM | 7.47 | Inhibition of B-Raf V600E mutant | 20597484 |
| Serine/threonine-protein kinase B-raf | IC50 | = | 3500.0 | nM | 5.46 | Inhibition of BRAF V600E mutant-mediated ERK phosphorylation in human WM266.4 ce... | 20597484 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 20597484 | 10.1021/jm100383b | Serine/threonine-protein kinase B-raf | 2 |
| 20597484 | 10.1021/jm100383b | NON-PROTEIN TARGET | 1 |
Data from ChEMBL 36 via Core Engine