Compound Detail
CHEMBL12259
UCM-5600 Enter ChEMBL ID:
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Basic Information
| ChEMBL ID | CHEMBL12259 |
| Name | UCM-5600 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | UPZHUDFDXXFEKG-UHFFFAOYSA-N |
2
Targets
5
Activities
1
Assay Types
0
PK Parameters
6
Publications
0
Known Names
Molecular Properties
399.5
MW (Da)
4.79
ALogP
3
HBA
0
HBD
26.8
PSA (Ų)
0.53
QED
0
Ro5 Violations
7
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
Ki 5 meas. best 7.1
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| 5-hydroxytryptamine receptor 7 CHEMBL3223 | Ki | 7.1 | 7.0833 | 79.4 | 3 |
| 5-hydroxytryptamine receptor 7 CHEMBL3155 | Ki | 7.05 | 7.05 | 89.0 | 2 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| 5-hydroxytryptamine receptor 7 | Ki | = | 79.43 | nM | 7.1 | Binding affinity towards 5-hydroxytryptamine receptor 7 on rat hypothalamus memb... | 14667218 |
| 5-hydroxytryptamine receptor 7 | Ki | = | 79.43 | nM | 7.1 | Binding affinity against 5-hydroxytryptamine 7 receptor using [3H]-5-CT in rat h... | 10843226 |
| 5-hydroxytryptamine receptor 7 | Ki | = | 89.0 | nM | 7.05 | Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHOK1 ... | 19326916 |
| 5-hydroxytryptamine receptor 7 | Ki | = | 89.0 | nM | 7.05 | Displacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells af... | 25128671 |
| 5-hydroxytryptamine receptor 7 | Ki | = | 89.0 | nM | 7.05 | Displacement of [3H]-5-CT from from 5-HT7 receptor in rat hypothalamus membranes... | 29767995 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 25128671 | 10.1016/j.ejmech.2014.08.023 | 5-hydroxytryptamine receptor 7 | 2 |
| 14667218 | 10.1021/jm030841r | 5-hydroxytryptamine receptor 7 | 1 |
| 10843226 | 10.1016/s0960-894x(00)00166-9 | 5-hydroxytryptamine receptor 7 | 1 |
| 19326916 | 10.1021/jm8014553 | 5-hydroxytryptamine receptor 7 | 1 |
| 19326916 | 10.1021/jm8014553 | 5-hydroxytryptamine receptor 1A | 1 |
| 29767995 | 10.1021/acs.jmedchem.7b01898 | 5-hydroxytryptamine receptor 7 | 1 |
Data from ChEMBL 36 via Core Engine