Compound Detail
CHEMBL1231574
LEVOMEFOLIC ACID 💊 Approved Drug
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💊 Approved Drug
CN1c2c([nH]c(N)nc2=O)NC[C@@H]1CNc1ccc(C(=O)N[C@@H](CCC(=O)O)C(=O)O)cc1
Basic Information
| ChEMBL ID | CHEMBL1231574 |
| Name | LEVOMEFOLIC ACID |
| Phase | Approved |
| Structure Type | MOL |
| InChI Key | ZNOVTXRBGFNYRX-STQMWFEESA-N |
| Therapeutic | ✓ Yes |
1
Targets
2
Activities
1
Assay Types
0
PK Parameters
3
Publications
14
Known Names
1
Indications
Molecular Properties
459.5
MW (Da)
-0.26
ALogP
9
HBA
7
HBD
202.8
PSA (Ų)
0.26
QED
1
Ro5 Violations
9
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| First Approval | 2010 |
| Availability | Prescription |
| Chirality | Single Enantiomer |
Indications
Attention Deficit Disorder with Hyperactivity
Activity Summary
Ki 2 meas. best 5.92
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Solute carrier organic anion transporter family member 1A3 CHEMBL2073707 | Ki | 5.92 | 5.92 | 1200.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Solute carrier organic anion transporter family member 1A3 | Ki | = | 1200.0 | nM | 5.92 | TP_TRANSPORTER: inhibition of MTX uptake in OAT-K1-expressing MDCK cells | 10869408 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 9756510 | 10.1152/ajpgi.1998.275.4.g789 | ATP-binding cassette sub-family C member 2 | 2 |
| - | 10.6019/CHEMBL4808148 | Histone deacetylase 6 | 2 |
| 10869408 | - | Solute carrier organic anion transporter family member 1A3 | 1 |
Data from ChEMBL 36 via Core Engine