Compound Detail
CHEMBL1232189
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Basic Information
| ChEMBL ID | CHEMBL1232189 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | RPGZQOOZHIEPJW-HNNXBMFYSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
409.4
MW (Da)
1.65
ALogP
6
HBA
4
HBD
103.6
PSA (Ų)
0.46
QED
0
Ro5 Violations
6
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
Kd 1 meas. best 10.3
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Glycogen synthase kinase-3 beta CHEMBL262 | Kd | 10.3 | 10.3 | 0.1 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Glycogen synthase kinase-3 beta | Kd | = | 0.05 | nM | 10.3 | Binding affinity to GSK-3beta (unknown origin) assessed as dissociation constant | 37536264 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 37536264 | 10.1016/j.bmc.2023.117406 | Glycogen synthase kinase-3 beta | 1 |
Data from ChEMBL 36 via Core Engine