Compound Detail
CHEMBL1252
ABARELIX 💊 Approved Drug
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💊 Approved Drug
CC(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N[C@H](Cc1cccnc1)C(=O)N[C@@H](CO)C(=O)N(C)[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCNC(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(N)=O
Basic Information
| ChEMBL ID | CHEMBL1252 |
| Name | ABARELIX |
| Phase | Approved |
| Structure Type | BOTH |
| InChI Key | AIWRTTMUVOZGPW-HSPKUQOVSA-N |
| Therapeutic | ✓ Yes |
1
Targets
2
Activities
2
Assay Types
0
PK Parameters
2
Publications
7
Known Names
2
Indications
1
Mechanisms
Molecular Properties
1416.1
MW (Da)
Drug Information
| Molecule Type | Protein |
| First Approval | 2003 |
| Availability | Discontinued |
| Chirality | Single Enantiomer |
Mechanism of Action
| Mechanism | Action Type | Target | Direct | Efficacy |
|---|---|---|---|---|
| Gonadotropin-releasing hormone receptor antagonist | ANTAGONIST | Gonadotropin-releasing hormone receptor | ✓ | ✓ |
Indications
Neoplasms Prostatic Neoplasms, Castration-Resistant
ATC Classification
L02BX01
abarelix
Level 1: ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
Level 2: ENDOCRINE THERAPY
Drug Warnings
Black Box Warning
General Warning
Activity Summary
IC50 1 meas. best 8.46
Kd 1 meas. best 9.1
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Gonadotropin-releasing hormone receptor CHEMBL1855 | Kd | 9.1 | 9.1 | 0.8 | 1 |
| Gonadotropin-releasing hormone receptor CHEMBL1855 | IC50 | 8.46 | 8.46 | 3.5 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Gonadotropin-releasing hormone receptor | Kd | = | 0.7943 | nM | 9.1 | Competitive antagonism of GnRH-induced response in the reporter gene assay | 11462984 |
| Gonadotropin-releasing hormone receptor | IC50 | = | 3.5 | nM | 8.46 | Antagonism of human GnHR receptor, determined in a reporter gene assay in HEK293... | 11462984 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 11462984 | 10.1021/jm0003900 | Gonadotropin-releasing hormone receptor | 2 |
| 11462984 | 10.1021/jm0003900 | Rattus norvegicus | 1 |
Data from ChEMBL 36 via Core Engine