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Compound Detail

CHEMBL125302

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O=C(O)[C@H]1[C@H](Cn2nnc3ccccc3c2=O)CC[C@@H]1Sc1ccc(-c2nccs2)cc1

Basic Information

ChEMBL ID CHEMBL125302
Phase Preclinical
Structure Type MOL
InChI Key KZZHUKUOPGQIRQ-YSSFQJQWSA-N
0
Targets
0
Activities
0
Assay Types
0
PK Parameters
5
Publications
0
Known Names

Molecular Properties

464.6
MW (Da)
4.19
ALogP
8
HBA
1
HBD
98.0
PSA (Ų)
0.46
QED
0
Ro5 Violations
6
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C23H20N4O3S2
MW 464.57
Aromatic Rings 4
Heavy Atoms 32
NP-Likeness -1.28

Literature References

PubMed DOI Target Context # Activities
12930146 10.1021/jm0307638 Interstitial collagenase 1
12930146 10.1021/jm0307638 72 kDa type IV collagenase 1
12930146 10.1021/jm0307638 Stromelysin-1 1
12930146 10.1021/jm0307638 Matrix metalloproteinase-9 1
12930146 10.1021/jm0307638 Collagenase 3 1

Data from ChEMBL 36 via Core Engine