Compound Detail
CHEMBL1256030
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Basic Information
| ChEMBL ID | CHEMBL1256030 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | JEWFYHMAOAFLDP-KHQFGBGNSA-N |
1
Targets
6
Activities
1
Assay Types
0
PK Parameters
6
Publications
0
Known Names
Molecular Properties
296.4
MW (Da)
-0.83
ALogP
8
HBA
4
HBD
115.7
PSA (Ų)
0.58
QED
0
Ro5 Violations
3
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
Ki 6 meas. best 7.72
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Unchecked CHEMBL612545 | Ki | 7.72 | 6.4933 | 19.0 | 3 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Unchecked | Ki | = | 19.0 | nM | 7.72 | Inhibition of Trypanosoma vivax Inosine-adenosine-guanosine-nucleoside hydrolase | 20194690 |
| Unchecked | Ki | = | 56.0 | nM | 7.25 | Inhibition of Trypanosoma brucei brucei inosine-adenosine-guanosine nucleoside h... | 20194690 |
| Unchecked | Ki | = | 31000.0 | nM | 4.51 | Inhibition of Trypanosoma brucei brucei Inosine guanosine nucleoside hydrolase | 20194690 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 20194690 | 10.1128/aac.01787-09 | Unchecked | 7 |
| 20194690 | 10.1128/aac.01787-09 | Trypanosoma brucei brucei | 1 |
| 20194690 | 10.1128/aac.01787-09 | ADMET | 1 |
| 20194690 | 10.1128/aac.01787-09 | Trypanosoma cruzi | 1 |
| 20194690 | 10.1128/aac.01787-09 | Leishmania infantum | 1 |
| 20194690 | 10.1128/aac.01787-09 | Plasmodium falciparum | 1 |
Data from ChEMBL 36 via Core Engine