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Compound Detail

CHEMBL1256137

CYSTEAMINE HYDROCHLORIDE
💊 Approved Drug
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💊 Approved Drug

Basic Information

ChEMBL ID CHEMBL1256137
Name CYSTEAMINE HYDROCHLORIDE
Phase Approved
Structure Type MOL
InChI Key OGMADIBCHLQMIP-UHFFFAOYSA-N
Therapeutic ✓ Yes
Parent Compound CHEMBL602
Active Moiety CHEMBL602

Known Names

CI-9148 Cystadrops Cystaran Cysteamine hcl Cysteamine hydrochloride Mercaptamine hydrochloride NSC-21116 NSC-25116 NSC-758692
0
Targets
1
Activities
1
Assay Types
0
PK Parameters
10
Publications
9
Known Names
1
Indications
1
Mechanisms

Molecular Properties

77.2
MW (Da)
-0.13
ALogP
2
HBA
2
HBD
26.0
PSA (Ų)
0.42
QED
0
Ro5 Violations
1
Rot. Bonds

Drug Information

Molecule Type Small molecule
First Approval 2012
Availability Prescription
Chirality Achiral

Routes of Administration

Topical
USAN Year 1991

Extended Properties

Molecular Formula C2H8ClNS
MW 113.61
Aromatic Rings 0
Heavy Atoms 4
NP-Likeness 0.18

Mechanism of Action

Mechanism Action Type Target Direct Efficacy
Cystine reducing agent REDUCING AGENT Cystine ✓ ✓

Indications

Cystinosis

Activity Summary

EC50 1 meas.

Literature References

PubMed DOI Target Context # Activities
26774926 10.1016/j.ejmech.2015.12.027 No relevant target 5
26774926 10.1016/j.ejmech.2015.12.027 ADMET 3
- 10.6019/CHEMBL4495565 SARS-CoV-2 2
- 10.6019/CHEMBL4808148 Histone deacetylase 6 2
17417631 10.1038/nchembio873 Unchecked 1
26774926 10.1016/j.ejmech.2015.12.027 HaCaT 1
- 10.21203/rs.3.rs-23951/v1 SARS-CoV-2 1
- 10.6019/CHEMBL4495564 Replicase polyprotein 1ab 1
33744437 10.1016/j.bmcl.2021.127958 Aldehyde dehydrogenase 1A1 1
33744437 10.1016/j.bmcl.2021.127958 Aldehyde dehydrogenase, mitochondrial 1

Data from ChEMBL 36 via Core Engine