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Compound Detail

CHEMBL126193

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CCCOc1nsnc1OC1CN2CCC1CC2

Basic Information

ChEMBL ID CHEMBL126193
Phase Preclinical
Structure Type MOL
InChI Key ZCWFZQVJDGFYIY-UHFFFAOYSA-N
1
Targets
2
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names

Molecular Properties

269.4
MW (Da)
1.80
ALogP
6
HBA
0
HBD
47.5
PSA (Ų)
0.82
QED
0
Ro5 Violations
5
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C12H19N3O2S
MW 269.37
Aromatic Rings 1
Heavy Atoms 18
NP-Likeness -0.47

Activity Summary

IC50 2 meas. best 7.9

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Muscarinic acetylcholine receptor M1
CHEMBL276
IC50 7.9 7.625 12.5 2

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
9464368 10.1021/jm970125n Muscarinic acetylcholine receptor M1 4
9464368 10.1021/jm970125n Mus musculus 1

Data from ChEMBL 36 via Core Engine