Compound Detail
CHEMBL1269264
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CC(C)N(Cc1ccccc1)C(=O)CN1C(=O)[C@H](c2c[nH]c3ccccc23)c2nnc(-c3ccccc3)n2-c2ccccc21
Basic Information
| ChEMBL ID | CHEMBL1269264 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | CFRYWCUTRXGKBW-MGBGTMOVSA-N |
1
Targets
1
Activities
1
Assay Types
1
PK Parameters
5
Publications
0
Known Names
Molecular Properties
580.7
MW (Da)
6.33
ALogP
5
HBA
1
HBD
87.1
PSA (Ų)
0.24
QED
2
Ro5 Violations
7
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 6.61
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Cholecystokinin receptor type A CHEMBL1901 | IC50 | 6.61 | 6.61 | 246.0 | 1 |
Pharmacokinetic Data
| Parameter | Value | Units | Species |
|---|---|---|---|
| CL | - | - | Homo sapiens |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Cholecystokinin receptor type A | IC50 | = | 246.0 | nM | 6.61 | Displacement of [125I]CCK8 from human CCK1 receptor expressed in CHO cells | 20851601 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 20851601 | 10.1016/j.bmcl.2010.08.115 | Cholecystokinin receptor type A | 4 |
| 20851601 | 10.1016/j.bmcl.2010.08.115 | No relevant target | 2 |
| 20851601 | 10.1016/j.bmcl.2010.08.115 | Mus musculus | 2 |
| 20851601 | 10.1016/j.bmcl.2010.08.115 | Liver microsomes | 1 |
| 20851601 | 10.1016/j.bmcl.2010.08.115 | Rattus norvegicus | 1 |
Data from ChEMBL 36 via Core Engine