Compound Detail
CHEMBL1270169
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Basic Information
| ChEMBL ID | CHEMBL1270169 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | LCHYXWHFOJGIHN-UHFFFAOYSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
9
Publications
0
Known Names
Molecular Properties
375.5
MW (Da)
4.91
ALogP
4
HBA
0
HBD
49.6
PSA (Ų)
0.35
QED
0
Ro5 Violations
6
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 5.0
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| PH domain leucine-rich repeat-containing protein phosphatase 2 CHEMBL1275209 | IC50 | 5.0 | 5.0 | 10000.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| PH domain leucine-rich repeat-containing protein phosphatase 2 | IC50 | = | 10000.0 | nM | 5.0 | Inhibition of PHLPP2 phosphatase domain expressed in Escherichia coli | 20836557 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 20836557 | 10.1021/jm100331d | PH domain leucine-rich repeat-containing protein phosphatase 2 | 1 |
| 20836557 | 10.1021/jm100331d | Unchecked | 1 |
| - | 10.6019/CHEMBL4296182 | Escherichia coli | 1 |
| - | 10.6019/CHEMBL4296182 | Candida albicans | 1 |
| - | 10.6019/CHEMBL4296182 | Cryptococcus neoformans | 1 |
| - | 10.6019/CHEMBL4296182 | Staphylococcus aureus | 1 |
| - | 10.6019/CHEMBL4296182 | Acinetobacter baumannii | 1 |
| - | 10.6019/CHEMBL4296182 | Pseudomonas aeruginosa | 1 |
| - | 10.6019/CHEMBL4296182 | Klebsiella pneumoniae | 1 |
Data from ChEMBL 36 via Core Engine