Compound Detail
CHEMBL1270280
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Basic Information
| ChEMBL ID | CHEMBL1270280 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | SEOHGWZXTWJVDE-UHFFFAOYSA-N |
1
Targets
2
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
487.6
MW (Da)
2.93
ALogP
10
HBA
2
HBD
107.6
PSA (Ų)
0.42
QED
0
Ro5 Violations
6
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 9.05
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Ephrin type-B receptor 4 CHEMBL5147 | IC50 | 9.05 | 8.675 | 0.9 | 2 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Ephrin type-B receptor 4 | IC50 | = | 0.9 | nM | 9.05 | Inhibition of EphB4 by acoustic dispensing assay | 20850301 |
| Ephrin type-B receptor 4 | IC50 | = | 5.0 | nM | 8.3 | Inhibition of EphB4 autophosphorylation expressed in CHOK1 cells | 20850301 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 20850301 | 10.1016/j.bmcl.2010.08.100 | Ephrin type-B receptor 4 | 2 |
| - | 10.6019/CHEMBL3301361 | No relevant target | 1 |
Data from ChEMBL 36 via Core Engine