Compound Detail
CHEMBL1328913
DIMETACRINE 🧪 Phase II
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
🧪 Phase II
Basic Information
| ChEMBL ID | CHEMBL1328913 |
| Name | DIMETACRINE |
| Phase | Phase II |
| Structure Type | MOL |
| InChI Key | RYQOGSFEJBUZBX-UHFFFAOYSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
4
Publications
5
Known Names
1
Indications
Molecular Properties
294.4
MW (Da)
4.42
ALogP
2
HBA
0
HBD
6.5
PSA (Ų)
0.82
QED
0
Ro5 Violations
4
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Chirality | Achiral |
Indications
Depressive Disorder
ATC Classification
N06AA18
dimetacrine
Level 1: NERVOUS SYSTEM
Level 2: PSYCHOANALEPTICS
Activity Summary
IC50 1 meas. best 4.55
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Apical membrane antigen 1 CHEMBL3559647 | IC50 | 4.55 | 4.55 | 28000.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Apical membrane antigen 1 | IC50 | = | 28000.0 | nM | 4.55 | Binding affinity to recombinant His-tagged Plasmodium falciparum 3D7 AMA1 assess... | - |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 15646539 | 10.1016/s0399-8320(04)95062-2 | Unchecked | 11 |
| 15646539 | 10.1016/s0399-8320(04)95062-2 | NON-PROTEIN TARGET | 8 |
| 20020916 | 10.1080/15376510701857262 | Phospholipidosis | 1 |
| - | 10.1039/C4MD00090K | Apical membrane antigen 1 | 1 |
Data from ChEMBL 36 via Core Engine