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Compound Detail

CHEMBL134754

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CCc1nc2c(C)cc(C)nc2n1Cc1ccc(N(C)C(C(=O)O)c2cc(F)ccc2F)cc1
ChEMBL ↗ Properties Compare Identifier

Basic Information

ChEMBL ID CHEMBL134754
Phase Preclinical
Structure Type MOL
InChI Key YRGPNLQAYCXLSM-UHFFFAOYSA-N
0
Targets
0
Activities
0
Assay Types
0
PK Parameters
2
Publications
0
Known Names

Molecular Properties

464.5
MW (Da)
5.20
ALogP
5
HBA
1
HBD
71.2
PSA (Ų)
0.41
QED
1
Ro5 Violations
7
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C26H26F2N4O2
MW 464.52
Aromatic Rings 4
Heavy Atoms 34
NP-Likeness -1.70

Literature References

PubMed DOI Target Context # Activities
8277506 10.1021/jm00078a014 Type-1 angiotensin II receptor 1
8277506 10.1021/jm00078a014 Type-2 angiotensin II receptor 1

Data from ChEMBL 36 via Core Engine