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Compound Detail

CHEMBL1352

NITRIC ACID
🧪 Phase III
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🧪 Phase III

Basic Information

ChEMBL ID CHEMBL1352
Name NITRIC ACID
Phase Phase III
Structure Type MOL
InChI Key GRYLNZFGIOXLOG-UHFFFAOYSA-N

Known Names

Nitric acid
1
Targets
24
Activities
1
Assay Types
0
PK Parameters
20
Publications
1
Known Names
9
Indications

Molecular Properties

63.0
MW (Da)
-0.35
ALogP
2
HBA
1
HBD
63.4
PSA (Ų)
0.31
QED
0
Ro5 Violations
0
Rot. Bonds

Drug Information

Molecule Type Small molecule
Chirality Achiral

Flags

Natural Product

Extended Properties

Molecular Formula HNO3
MW 63.01
Aromatic Rings 0
Heavy Atoms 4
NP-Likeness -0.98

Indications

Pancreatitis Reperfusion Injury Coronary Disease Heart Failure Heart Failure, Systolic Menopause Prostatic Neoplasms Prostatic Neoplasms, Castration-Resistant Respiratory Insufficiency

Activity Summary

Ki 24 meas. best 7.8

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Carbonic anhydrase V
CHEMBL2111457
 Ki 7.8 7.8 16.0 1

Activity Data Samples

Top measurements by pChEMBL value

Target Type Rel. Value Units pChEMBL Assay PubMed
Carbonic anhydrase V Ki = 16.0 nM 7.8 Inhibitory activity against human carbonic anhydrase V expressed in Escherichia ... 15454240

Literature References

PubMed DOI Target Context # Activities
15357993 10.1016/j.bmcl.2004.06.073 Carbonic anhydrase 2
15454240 10.1016/j.bmcl.2004.07.086 Carbonic anhydrase 2 1
21208801 10.1016/j.bmcl.2010.11.124 Carbonic anhydrase 1
21208801 10.1016/j.bmcl.2010.11.124 Carbonic anhydrase 1 1
16621537 10.1016/j.bmcl.2006.03.078 Carbonic anhydrase 7 1
15501038 10.1016/j.bmcl.2004.09.063 Carbonic anhydrase 9 1
15501038 10.1016/j.bmcl.2004.09.063 Carbonic anhydrase V 1
15501038 10.1016/j.bmcl.2004.09.063 Carbonic anhydrase 4 1
15501038 10.1016/j.bmcl.2004.09.063 Carbonic anhydrase 2 1
15501038 10.1016/j.bmcl.2004.09.063 Carbonic anhydrase 1 1
15454240 10.1016/j.bmcl.2004.07.086 Carbonic anhydrase 13 1
15454240 10.1016/j.bmcl.2004.07.086 Carbonic anhydrase V 1
15664814 10.1016/j.bmcl.2004.11.056 Carbonic anhydrase 1 1
15454240 10.1016/j.bmcl.2004.07.086 Carbonic anhydrase 1 1
15357993 10.1016/j.bmcl.2004.06.073 Carbonic anhydrase 4 1
15357993 10.1016/j.bmcl.2004.06.073 Carbonic anhydrase 2 1
15357993 10.1016/j.bmcl.2004.06.073 Carbonic anhydrase 1 1
15664814 10.1016/j.bmcl.2004.11.056 Carbonic anhydrase 9 1
15664814 10.1016/j.bmcl.2004.11.056 Carbonic anhydrase 5A, mitochondrial 1
15664814 10.1016/j.bmcl.2004.11.056 Carbonic anhydrase 4 1

Data from ChEMBL 36 via Core Engine