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Compound Detail

CHEMBL1353

SODIUM BICARBONATE
💊 Approved Drug
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💊 Approved Drug
O=C([O-])O.[Na+]
ChEMBL ↗ Properties Compare Identifier

Basic Information

ChEMBL ID CHEMBL1353
Name SODIUM BICARBONATE
Phase Approved
Structure Type MOL
InChI Key UIIMBOGNXHQVGW-UHFFFAOYSA-M

Known Names

B1654 Baking soda Bicarbonate of soda Carbonic acid monosodium salt Carbonic acid sodium salt (1:1) E-500(II) Genitron tp-bch 51051 Hydrocerol esc 5671 INS NO.500(II) INS-500(II) Monosodium carbonate Nabic +18 more
1
Targets
76
Activities
1
Assay Types
0
PK Parameters
20
Publications
30
Known Names
20
Indications

Molecular Properties

84.0
MW (Da)

Drug Information

Molecule Type Small molecule
First Approval 1982
Availability OTC
Chirality Achiral

Routes of Administration

Oral Parenteral

Flags

Black Box Warning

Extended Properties

Molecular Formula CHNaO3
MW 84.01

Indications

Acid-Base Imbalance Fluid Therapy Gastroesophageal Reflux Heartburn Pain Acute Kidney Injury Acute Kidney Injury Constipation Gastrointestinal Hemorrhage Kidney Diseases Oropharyngeal Neoplasms Pharyngeal Neoplasms Pulpitis Renal Insufficiency Renal Insufficiency, Chronic Severe Acute Respiratory Syndrome Heart Diseases Hematologic Diseases Neoplasms Tension-Type Headache

ATC Classification

B05CB04
sodium bicarbonate
Level 1: BLOOD AND BLOOD FORMING ORGANS
Level 2: BLOOD SUBSTITUTES AND PERFUSION SOLUTIONS
B05XA02
sodium bicarbonate
Level 1: BLOOD AND BLOOD FORMING ORGANS
Level 2: BLOOD SUBSTITUTES AND PERFUSION SOLUTIONS

Drug Warnings

Black Box Warning
misuse
Country: United States

Activity Summary

Ki 76 meas. best 4.0

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Unchecked
CHEMBL612545
 Ki 4.0 4.0 100000.0 1

Activity Data Samples

Top measurements by pChEMBL value

Target Type Rel. Value Units pChEMBL Assay PubMed
Unchecked Ki = 100000.0 nM 4.0 Inhibition of Leptonychotes weddellii alpha-carbonic anhydrase after 15 mins by ... 21377369

Literature References

PubMed DOI Target Context # Activities
22194678 10.1371/journal.pcbi.1002310 Hepatotoxicity 14
- 10.1016/j.cropro.2007.02.008 Colletotrichum musae 12
- 10.1016/j.cropro.2007.02.008 Lasiodiplodia theobromae 12
- 10.1016/j.cropro.2007.02.008 Fusarium verticillioides 12
- 10.1016/j.cropro.2007.02.008 Thielaviopsis paradoxa 12
- 10.1016/j.cropro.2006.01.002 Malus domestica 10
- 10.1016/j.cropro.2006.01.002 Venturia inaequalis 8
27914949 10.1016/j.bmc.2016.11.021 Unchecked 4
26145820 10.1016/j.bmc.2015.06.021 Unchecked 3
23200251 10.1016/j.bmcl.2012.10.103 Unchecked 3
20014752 10.1021/tx900326k Hepatotoxicity 3
22835873 10.1016/j.bmcl.2012.06.106 Unchecked 2
21570835 10.1016/j.bmcl.2011.04.105 Unchecked 2
24461298 10.1016/j.bmcl.2013.12.124 Unchecked 2
28238511 10.1016/j.bmc.2017.02.032 Unchecked 2
- 10.6019/CHEMBL4495565 SARS-CoV-2 2
25168748 10.1016/j.bmcl.2014.08.014 Unchecked 2
23414801 10.1016/j.bmcl.2013.01.087 Unchecked 2
23790722 10.1016/j.bmc.2013.05.058 Unchecked 2
26948801 10.1016/j.drudis.2016.02.015 Homo sapiens 2

Data from ChEMBL 36 via Core Engine