Compound Detail
CHEMBL140184
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
Basic Information
| ChEMBL ID | CHEMBL140184 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | IJICKINLCUKIHY-UHFFFAOYSA-N |
2
Targets
3
Activities
1
Assay Types
0
PK Parameters
4
Publications
1
Known Names
Molecular Properties
273.4
MW (Da)
3.60
ALogP
2
HBA
0
HBD
12.5
PSA (Ų)
0.81
QED
0
Ro5 Violations
5
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
Ki 3 meas. best 7.9
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| D(3) dopamine receptor CHEMBL234 | Ki | 7.9 | 7.895 | 12.6 | 2 |
| D(2) dopamine receptor CHEMBL217 | Ki | 6.6 | 6.6 | 251.2 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| D(3) dopamine receptor | Ki | = | 12.59 | nM | 7.9 | Inhibition of [125 I]iodosulpiride binding to human Dopamine receptor D3 express... | - |
| D(3) dopamine receptor | Ki | = | 13.0 | nM | 7.89 | Displacement of [125I]iodosulpiride from human Dopamine receptor D3 expressed in... | 14521403 |
| D(2) dopamine receptor | Ki | = | 251.19 | nM | 6.6 | Inhibition of [125 I]iodosulpiride binding to human Dopamine receptor D2 express... | - |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 14521403 | 10.1021/jm030085p | D(3) dopamine receptor | 1 |
| - | 10.1016/S0960-894X(97)00126-1 | D(2) dopamine receptor | 1 |
| - | 10.1016/S0960-894X(97)00126-1 | D(3) dopamine receptor | 1 |
| - | 10.1016/S0960-894X(97)00126-1 | Dopamine receptors; D2 & D3 | 1 |
Data from ChEMBL 36 via Core Engine