Compound Detail
CHEMBL1436
CEFUROXIME 💊 Approved Drug
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💊 Approved Drug
CO/N=C(\C(=O)N[C@@H]1C(=O)N2C(C(=O)O)=C(COC(N)=O)CS[C@H]12)c1ccco1
Basic Information
| ChEMBL ID | CHEMBL1436 |
| Name | CEFUROXIME |
| Phase | Approved |
| Structure Type | MOL |
| InChI Key | JFPVXVDWJQMJEE-IZRZKJBUSA-N |
| Therapeutic | ✓ Yes |
0
Targets
5
Activities
1
Assay Types
10
PK Parameters
20
Publications
5
Known Names
6
Indications
Molecular Properties
424.4
MW (Da)
-0.54
ALogP
9
HBA
3
HBD
173.8
PSA (Ų)
0.30
QED
0
Ro5 Violations
7
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| First Approval | 1983 |
| Availability | Prescription |
| Chirality | Single Enantiomer |
Indications
Bacterial Infections Eye Infections Pneumonia Appendicitis Endophthalmitis Osteomyelitis
ATC Classification
J01DC02
cefuroxime
Level 1: ANTIINFECTIVES FOR SYSTEMIC USE
Level 2: ANTIBACTERIALS FOR SYSTEMIC USE
S01AA27
cefuroxime
Level 1: SENSORY ORGANS
Level 2: OPHTHALMOLOGICALS
Activity Summary
Ki 5 meas.
Pharmacokinetic Data
| Parameter | Value | Units | Species |
|---|---|---|---|
| CL | 2.2 | mL.min-1.kg-1 | Homo sapiens |
| CL | 2.2 | mL.min-1.kg-1 | Homo sapiens |
| CL | 0.1 | mL.min-1.kg-1 | Homo sapiens |
| CL | 2.2 | mL.min-1.kg-1 | Homo sapiens |
| Cmax | 61264.4 | nM | Homo sapiens |
| Fu | 0.36 | - | Homo sapiens |
| Fu | 0.12 | - | Homo sapiens |
| MRT | 1.1 | hr | Homo sapiens |
| T1/2 | 1.1 | hr | Homo sapiens |
| T1/2 | 1.5 | hr | Homo sapiens |
Literature References
Data from ChEMBL 36 via Core Engine