Compound Detail
CHEMBL1442
MTIC Enter ChEMBL ID:
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Basic Information
| ChEMBL ID | CHEMBL1442 |
| Name | MTIC |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | MVBPAIHFZZKRGD-UHFFFAOYSA-N |
1
Targets
2
Activities
1
Assay Types
1
PK Parameters
10
Publications
3
Known Names
Molecular Properties
168.2
MW (Da)
-0.27
ALogP
4
HBA
3
HBD
108.5
PSA (Ų)
0.43
QED
0
Ro5 Violations
3
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Achiral |
Activity Summary
IC50 2 meas. best 5.3
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| GM892A cell line CHEMBL614505 | IC50 | 5.3 | 5.3 | 5000.0 | 1 |
Pharmacokinetic Data
| Parameter | Value | Units | Species |
|---|---|---|---|
| T1/2 | 3.2 | hr | - |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| GM892A cell line | IC50 | = | 5000.0 | nM | 5.3 | In vitro cytotoxicity against human lymphoblastoid cell (GM892 A) | 7739008 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| - | 10.1039/C6MD00384B | SNB-19 | 2 |
| - | 10.1039/C6MD00384B | U373 MG | 2 |
| 30108945 | 10.1039/C7MD00554G | SNB-19 | 2 |
| 30108945 | 10.1039/C7MD00554G | U373 MG | 2 |
| 9857092 | 10.1021/jm980273t | ADMET | 1 |
| 7739008 | 10.1021/jm00009a010 | GM892A cell line | 1 |
| 7739008 | 10.1021/jm00009a010 | Raji | 1 |
| 7739008 | 10.1021/jm00009a010 | NON-PROTEIN TARGET | 1 |
| 15615536 | 10.1021/jm049556d | ADMET | 1 |
| - | 10.1039/C6MD00384B | dsDNA | 1 |
Data from ChEMBL 36 via Core Engine