Compound Detail
CHEMBL144835
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Basic Information
| ChEMBL ID | CHEMBL144835 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | UTWBPURYALKZBN-UHFFFAOYSA-N |
3
Targets
3
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names
Molecular Properties
316.4
MW (Da)
4.86
ALogP
2
HBA
0
HBD
8.2
PSA (Ų)
0.67
QED
0
Ro5 Violations
4
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
Ki 3 meas. best 8.05
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| D(4) dopamine receptor CHEMBL219 | Ki | 8.05 | 8.05 | 9.0 | 1 |
| D(2) dopamine receptor CHEMBL5456 | Ki | 7.68 | 7.68 | 21.0 | 1 |
| D(3) dopamine receptor CHEMBL2304406 | Ki | 7.21 | 7.21 | 61.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| D(4) dopamine receptor | Ki | = | 9.0 | nM | 8.05 | Displacement of [3H]-YM 09151 from human Dopamine receptor D4 | 8523409 |
| D(2) dopamine receptor | Ki | = | 21.0 | nM | 7.68 | Displacement of [3H]-YM 09151 from african green monkey Dopamine receptor D2 | 8523409 |
| D(3) dopamine receptor | Ki | = | 61.0 | nM | 7.21 | Displacement of [3H]-YM 09151 from african monkey Dopamine receptor D3 | 8523409 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 8523409 | 10.1021/jm00025a013 | D(2) dopamine receptor | 1 |
| 8523409 | 10.1021/jm00025a013 | D(3) dopamine receptor | 1 |
| 8523409 | 10.1021/jm00025a013 | D(4) dopamine receptor | 1 |
Data from ChEMBL 36 via Core Engine