Compound Detail
CHEMBL1449
TICARCILLIN 💊 Approved Drug
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💊 Approved Drug
CC1(C)S[C@@H]2[C@H](NC(=O)[C@H](C(=O)O)c3ccsc3)C(=O)N2[C@H]1C(=O)O
Basic Information
| ChEMBL ID | CHEMBL1449 |
| Name | TICARCILLIN |
| Phase | Approved |
| Structure Type | MOL |
| InChI Key | OHKOGUYZJXTSFX-KZFFXBSXSA-N |
| Therapeutic | ✓ Yes |
0
Targets
5
Activities
2
Assay Types
5
PK Parameters
20
Publications
3
Known Names
4
Indications
Molecular Properties
384.4
MW (Da)
0.55
ALogP
6
HBA
3
HBD
124.0
PSA (Ų)
0.50
QED
0
Ro5 Violations
5
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| First Approval | 1976 |
| Availability | Discontinued |
| Chirality | Single Enantiomer |
Indications
Bacterial Infections Infections Sepsis Osteomyelitis
ATC Classification
J01CA13
ticarcillin
Level 1: ANTIINFECTIVES FOR SYSTEMIC USE
Level 2: ANTIBACTERIALS FOR SYSTEMIC USE
Activity Summary
Ki 4 meas.
IC50 1 meas.
Pharmacokinetic Data
| Parameter | Value | Units | Species |
|---|---|---|---|
| CL | 2.2 | mL.min-1.kg-1 | Homo sapiens |
| CL | 1.8 | mL.min-1.kg-1 | Homo sapiens |
| Fu | 0.55 | - | Homo sapiens |
| MRT | 1.5 | hr | Homo sapiens |
| T1/2 | 1.0 | hr | Homo sapiens |
Literature References
Data from ChEMBL 36 via Core Engine