Compound Detail
CHEMBL1449007
2-(2'-METHOXYPHENYL)-1H-INDOLE Enter ChEMBL ID:
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Basic Information
| ChEMBL ID | CHEMBL1449007 |
| Name | 2-(2'-METHOXYPHENYL)-1H-INDOLE |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | GYUBKMFGRAIVMZ-UHFFFAOYSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
6
Publications
0
Known Names
Molecular Properties
223.3
MW (Da)
3.84
ALogP
1
HBA
1
HBD
25.0
PSA (Ų)
0.70
QED
0
Ro5 Violations
2
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 4.33
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Mitochondrial import inner membrane translocase subunit TIM10 CHEMBL1741194 | IC50 | 4.33 | 4.33 | 46900.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Mitochondrial import inner membrane translocase subunit TIM10 | IC50 | = | 46900.0 | nM | 4.33 | PUBCHEM_BIOASSAY: Dose Response confirmation of uHTS small molecule inhibitors o... | - |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 30568753 | 10.1039/C8MD00436F | Unchecked | 3 |
| 23419325 | 10.1016/j.bmc.2013.01.032 | NON-PROTEIN TARGET | 2 |
| 23419325 | 10.1016/j.bmc.2013.01.032 | U-87 MG | 1 |
| 23419325 | 10.1016/j.bmc.2013.01.032 | Unchecked | 1 |
| 30568753 | 10.1039/C8MD00436F | U-87 MG | 1 |
| 30568753 | 10.1039/C8MD00436F | U-251 | 1 |
Data from ChEMBL 36 via Core Engine