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Compound Detail

CHEMBL1491962

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Cc1csc(NC(=O)CSc2ccc(-c3ccccc3)nn2)n1

Basic Information

ChEMBL ID CHEMBL1491962
Phase Preclinical
Structure Type MOL
InChI Key WJRWSLORVIHRNX-UHFFFAOYSA-N
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
9
Publications
0
Known Names

Molecular Properties

342.4
MW (Da)
3.64
ALogP
6
HBA
1
HBD
67.8
PSA (Ų)
0.72
QED
0
Ro5 Violations
5
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C16H14N4OS2
MW 342.45
Aromatic Rings 3
Heavy Atoms 23
NP-Likeness -2.76

Activity Summary

IC50 2 meas. best 6.25

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Solute carrier family 12 member 5
CHEMBL1615384
IC50 6.25 6.25 568.0 1
Solute carrier family 12 member 2/member 5
CHEMBL3885641
IC50 6.25 6.25 560.0 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
- 10.6019/CHEMBL4495565 SARS-CoV-2 4
22727639 10.1016/j.bmcl.2012.05.126 Unchecked 2
- 10.6019/CHEMBL4495564 Replicase polyprotein 1ab 2
- 10.6019/CHEMBL4808148 Histone deacetylase 6 2
22727639 10.1016/j.bmcl.2012.05.126 Solute carrier family 12 member 5 1
22727639 10.1016/j.bmcl.2012.05.126 Voltage-gated inwardly rectifying potassium channel KCNH2 1
22727639 10.1016/j.bmcl.2012.05.126 Solute carrier family 12 member 2 1
- 10.21203/rs.3.rs-23951/v1 SARS-CoV-2 1
- 10.6019/EOS300108 HepG2 1

Data from ChEMBL 36 via Core Engine