Compound Detail
CHEMBL1510
ELETRIPTAN 💊 Approved Drug
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💊 Approved Drug
Basic Information
| ChEMBL ID | CHEMBL1510 |
| Name | ELETRIPTAN |
| Phase | Approved |
| Structure Type | MOL |
| InChI Key | PWVXXGRKLHYWKM-LJQANCHMSA-N |
| Therapeutic | ✓ Yes |
1
Targets
1
Activities
1
Assay Types
5
PK Parameters
20
Publications
6
Known Names
3
Indications
Molecular Properties
382.5
MW (Da)
3.82
ALogP
3
HBA
1
HBD
53.2
PSA (Ų)
0.71
QED
0
Ro5 Violations
6
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| First Approval | 2002 |
| Availability | Prescription |
| Chirality | Single Enantiomer |
Indications
Migraine Disorders Migraine with Aura Migraine without Aura
ATC Classification
N02CC06
eletriptan
Level 1: NERVOUS SYSTEM
Level 2: ANALGESICS
Activity Summary
EC50 1 meas. best 7.93
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| 5-hydroxytryptamine receptor 1B CHEMBL1898 | EC50 | 7.93 | 7.93 | 11.6 | 1 |
Pharmacokinetic Data
| Parameter | Value | Units | Species |
|---|---|---|---|
| CL | 5.3 | mL.min-1.kg-1 | Homo sapiens |
| F | 62.5 | % | Homo sapiens |
| Fu | 0.15 | - | Homo sapiens |
| MRT | 5.0 | hr | Homo sapiens |
| T1/2 | 4.2 | hr | Homo sapiens |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| 5-hydroxytryptamine receptor 1B | EC50 | = | 11.64 | nM | 7.93 | Agonist activity at 5-HT1B receptor (unknown origin) | 34922191 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| - | 10.5281/zenodo.13943903 | ADMET | 89 |
| 22194678 | 10.1371/journal.pcbi.1002310 | Hepatotoxicity | 14 |
| 11602674 | - | ATP-dependent translocase ABCB1 | 8 |
| 18426954 | 10.1124/dmd.108.020479 | ADMET | 4 |
| 37468498 | 10.1038/s41467-023-40064-9 | Thromboxane A2 receptor | 2 |
| - | 10.6019/CHEMBL4808148 | Histone deacetylase 6 | 2 |
| - | 10.6019/CHEMBL4651402 | SARS-CoV-2 | 2 |
| - | 10.6019/CHEMBL4495565 | SARS-CoV-2 | 2 |
| 37468498 | 10.1038/s41467-023-40064-9 | Muscarinic acetylcholine receptor M1 | 2 |
| 37468498 | 10.1038/s41467-023-40064-9 | Prostaglandin G/H synthase 1 | 2 |
| 24960305 | 10.1021/jm500364u | Homo sapiens | 2 |
| 26948801 | 10.1016/j.drudis.2016.02.015 | Homo sapiens | 2 |
| 37468498 | 10.1038/s41467-023-40064-9 | Alpha-1A adrenergic receptor | 2 |
| 24900570 | 10.1021/ml300314h | LLC-PK1 | 1 |
| - | 10.1101/2020.04.21.054387 | SARS-CoV-2 | 1 |
| 23033255 | 10.1124/dmd.112.048264 | Cytochrome P450 2J2 | 1 |
| 17870541 | 10.1016/j.bmc.2007.08.060 | Homo sapiens | 1 |
| 22541068 | 10.1021/jm300212s | Solute carrier organic anion transporter family member 1B1 | 1 |
| 22541068 | 10.1021/jm300212s | Solute carrier organic anion transporter family member 1B3 | 1 |
| 18426954 | 10.1124/dmd.108.020479 | NON-PROTEIN TARGET | 1 |
Data from ChEMBL 36 via Core Engine