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Compound Detail

CHEMBL151948

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COCC(=O)Nc1cc2ncnc(Nc3ccc(Cl)cc3F)c2cc1OC
ChEMBL ↗ Properties Compare Identifier

Basic Information

ChEMBL ID CHEMBL151948
Phase Preclinical
Structure Type MOL
InChI Key CQAALERBHGGYLB-UHFFFAOYSA-N
0
Targets
0
Activities
0
Assay Types
0
PK Parameters
3
Publications
0
Known Names

Molecular Properties

390.8
MW (Da)
3.76
ALogP
6
HBA
2
HBD
85.4
PSA (Ų)
0.67
QED
0
Ro5 Violations
6
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C18H16ClFN4O3
MW 390.80
Aromatic Rings 3
Heavy Atoms 27
NP-Likeness -1.96

Literature References

PubMed DOI Target Context # Activities
10639280 10.1021/jm990345w Vascular endothelial growth factor receptor 1 1
10639280 10.1021/jm990345w Vascular endothelial growth factor receptor 2 1
10639280 10.1021/jm990345w Fibroblast growth factor receptor 1 1

Data from ChEMBL 36 via Core Engine