Compound Detail
CHEMBL152612
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CC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)NC(Cc1c[nH]c2ccccc12)C(N)=O
Basic Information
| ChEMBL ID | CHEMBL152612 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | DFCJPPDAOZROBS-YFTKSLQMSA-N |
4
Targets
4
Activities
1
Assay Types
0
PK Parameters
4
Publications
0
Known Names
Molecular Properties
685.8
MW (Da)
-0.58
ALogP
7
HBA
9
HBD
268.4
PSA (Ų)
0.04
QED
2
Ro5 Violations
18
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
EC50 4 meas. best 8.4
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Melanocortin receptor 5 CHEMBL4489 | EC50 | 8.4 | 8.4 | 4.0 | 1 |
| Melanocortin receptor 4 CHEMBL3719 | EC50 | 7.76 | 7.76 | 17.2 | 1 |
| Melanocyte-stimulating hormone receptor CHEMBL4077 | EC50 | 7.7 | 7.7 | 20.1 | 1 |
| Melanocortin receptor 3 CHEMBL4774 | EC50 | 6.81 | 6.81 | 156.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Melanocortin receptor 5 | EC50 | = | 3.96 | nM | 8.4 | Activity in mouse melanocortin-5 receptor stably expressed in HEK293 cells | 12477357 |
| Melanocortin receptor 4 | EC50 | = | 17.2 | nM | 7.76 | Activity in mouse melanocortin-4 receptor stably expressed in HEK293 cells | 12477357 |
| Melanocyte-stimulating hormone receptor | EC50 | = | 20.1 | nM | 7.7 | Activity in mouse melanocortin-1 receptor stably expressed in HEK293 cells | 12477357 |
| Melanocortin receptor 3 | EC50 | = | 156.0 | nM | 6.81 | Activity in mouse melanocortin-3 receptor (mMC3R) stably expressed in HEK293 cel... | 12477357 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 12477357 | 10.1021/jm020296e | Melanocyte-stimulating hormone receptor | 1 |
| 12477357 | 10.1021/jm020296e | Melanocortin receptor 3 | 1 |
| 12477357 | 10.1021/jm020296e | Melanocortin receptor 4 | 1 |
| 12477357 | 10.1021/jm020296e | Melanocortin receptor 5 | 1 |
Data from ChEMBL 36 via Core Engine