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Compound Detail

CHEMBL1528

SODIUM FLUORIDE
💊 Approved Drug
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💊 Approved Drug

Basic Information

ChEMBL ID CHEMBL1528
Name SODIUM FLUORIDE
Phase Approved
Structure Type MOL
InChI Key PUZPDOWCWNUUKD-UHFFFAOYSA-M

Known Names

Dentalfluoro Dentiplus Duraphat En-de-kay Fluor ret Fluor-a-day Fluoride (as sodium fluoride) Fluoride (as sodium) Fluorigard Fluorigard daily Fluorigard weekly Nafril ret +12 more
0
Targets
30
Activities
3
Assay Types
0
PK Parameters
20
Publications
24
Known Names
13
Indications

Molecular Properties

42.0
MW (Da)

Drug Information

Molecule Type Small molecule
First Approval 1972
Availability Prescription
Chirality Achiral

Routes of Administration

Parenteral Topical

Extended Properties

Molecular Formula FNa
MW 41.99

Indications

Dental Caries Gingivitis Sensitivity and Specificity Bacterial Infections Familial Hypophosphatemic Rickets Hypersensitivity Mucositis Periodontal Diseases Periodontitis Tooth Diseases Osteoporosis, Postmenopausal Prostatic Neoplasms Fluorosis, Dental

ATC Classification

A01AA01
sodium fluoride
Level 1: ALIMENTARY TRACT AND METABOLISM
Level 2: STOMATOLOGICAL PREPARATIONS
A01AA51
sodium fluoride, combinations
Level 1: ALIMENTARY TRACT AND METABOLISM
Level 2: STOMATOLOGICAL PREPARATIONS
A12CD01
sodium fluoride
Level 1: ALIMENTARY TRACT AND METABOLISM
Level 2: MINERAL SUPPLEMENTS

Activity Summary

Ki 28 meas.
EC50 1 meas.
IC50 1 meas.

Literature References

PubMed DOI Target Context # Activities
27914949 10.1016/j.bmc.2016.11.021 Unchecked 4
23200251 10.1016/j.bmcl.2012.10.103 Unchecked 3
25008455 10.1016/j.bmcl.2014.06.035 NON-PROTEIN TARGET 3
26145820 10.1016/j.bmc.2015.06.021 Unchecked 3
21570835 10.1016/j.bmcl.2011.04.105 Unchecked 2
23414801 10.1016/j.bmcl.2013.01.087 Unchecked 2
23414807 10.1016/j.bmcl.2013.01.084 Unchecked 2
23790722 10.1016/j.bmc.2013.05.058 Unchecked 2
28238511 10.1016/j.bmc.2017.02.032 Unchecked 2
24461298 10.1016/j.bmcl.2013.12.124 Unchecked 2
22835873 10.1016/j.bmcl.2012.06.106 Unchecked 2
17726098 10.1073/pnas.0704482104 NON-PROTEIN TARGET 2
28754318 10.1016/j.bmc.2017.07.033 Unchecked 2
25168748 10.1016/j.bmcl.2014.08.014 Unchecked 2
17726098 10.1073/pnas.0704482104 Drosophila 2
17726098 10.1073/pnas.0704482104 Caenorhabditis elegans 2
22227210 10.1016/j.bmcl.2011.12.085 Astrosclerin-3 1
30895781 10.1021/acs.jmedchem.9b00164 Unchecked 1
21570835 10.1016/j.bmcl.2011.04.105 Carbonic anhydrase 2 1
21377369 10.1016/j.bmc.2011.02.015 Unchecked 1

Data from ChEMBL 36 via Core Engine