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Compound Detail

CHEMBL1531134

MELPERONE
🧪 Phase III
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🧪 Phase III
CC1CCN(CCCC(=O)c2ccc(F)cc2)CC1
ChEMBL ↗ Properties Compare Identifier

Basic Information

ChEMBL ID CHEMBL1531134
Name MELPERONE
Phase Phase III
Structure Type MOL
InChI Key DKMFBWQBDIGMHM-UHFFFAOYSA-N

Known Names

Bunil FG 5111 FG-5111 Melperona Melperone Metylperon
0
Targets
0
Activities
0
Assay Types
3
PK Parameters
20
Publications
6
Known Names
5
Indications

Molecular Properties

263.4
MW (Da)
3.52
ALogP
2
HBA
0
HBD
20.3
PSA (Ų)
0.76
QED
0
Ro5 Violations
5
Rot. Bonds

Drug Information

Molecule Type Small molecule
Chirality Achiral
USAN Stem -perone

Extended Properties

Molecular Formula C16H22FNO
MW 263.36
Aromatic Rings 1
Heavy Atoms 19
NP-Likeness -1.32

Indications

Anxiety Dementia Depressive Disorder Psychotic Disorders Schizophrenia

ATC Classification

N05AD03
melperone
Level 1: NERVOUS SYSTEM
Level 2: PSYCHOLEPTICS

Pharmacokinetic Data

Parameter Value Units Species
CL 46.0 mL.min-1.kg-1 Homo sapiens
MRT 5.0 hr Homo sapiens
T1/2 3.9 hr Homo sapiens

Literature References

PubMed DOI Target Context # Activities
15646539 10.1016/s0399-8320(04)95062-2 Unchecked 11
15646539 10.1016/s0399-8320(04)95062-2 NON-PROTEIN TARGET 8
18426954 10.1124/dmd.108.020479 ADMET 4
37468498 10.1038/s41467-023-40064-9 Thromboxane A2 receptor 2
37468498 10.1038/s41467-023-40064-9 Prostaglandin G/H synthase 1 2
37468498 10.1038/s41467-023-40064-9 Alpha-1A adrenergic receptor 2
- 10.6019/CHEMBL4888484 Plasmodium falciparum 2
- 10.6019/CHEMBL4808148 Histone deacetylase 6 2
- 10.6019/CHEMBL4651402 SARS-CoV-2 2
- 10.6019/CHEMBL4495565 SARS-CoV-2 2
37468498 10.1038/s41467-023-40064-9 Muscarinic acetylcholine receptor M1 2
- 10.6019/CHEMBL4495564 Replicase polyprotein 1ab 1
23956101 10.1093/toxsci/kft176 ATP-binding cassette sub-family C member 4 1
37468498 10.1038/s41467-023-40064-9 D(1A) dopamine receptor 1
37468498 10.1038/s41467-023-40064-9 Voltage-gated inwardly rectifying potassium channel KCNH2 1
37468498 10.1038/s41467-023-40064-9 Sodium-dependent dopamine transporter 1
23956101 10.1093/toxsci/kft176 ATP-binding cassette sub-family C member 3 1
37468498 10.1038/s41467-023-40064-9 Acetylcholinesterase 1
37468498 10.1038/s41467-023-40064-9 Sodium-dependent noradrenaline transporter 1
23956101 10.1093/toxsci/kft176 ATP-binding cassette sub-family C member 2 1

Data from ChEMBL 36 via Core Engine